No evidence for an association between ABO blood group and overall ischemic stroke or any of the major etiologic subtypes
Journal article, 2012

Introduction: The ABO blood group system is encoded by one gene, ABO. Previous studies have reported an association between blood group non-O (i.e. phenotype A, B or AB) and myocardial infarction. Studies on stroke and ABO are, however, more scarce. Therefore, we aimed to investigate whether ABO phenotype or genotype is associated with ischemic stroke and/or etiologic subtypes of ischemic stroke. Materials and methods: The study was performed in the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS), which comprises 600 patients with ischemic stroke before the age of 70 years, and 600 matched controls. Patients were classified according to the TOAST criteria. Results: There was no significant association between ABO phenotype (blood group O vs. non-O) and overall ischemic stroke (multivariable odds ratio of 0.9, 95% confidence interval 0.7-1.2). This was also true for blood group O vs. A and O vs. B. Furthermore, no association between ABO genotypes and ischemic stroke was detected. The ischemic stroke subtype analysis was confined to large-vessel disease, small-vessel disease, cardioembolic stroke and cryptogenic stroke. In this analysis, there was no significant association between any ischemic stroke subtype and ABO phenotype or genotype. Conclusions: The findings in this study suggest that ABO phenotype or genotype does not have a major impact in the pathophysiology of ischemic stroke or any of the ischemic stroke subtypes.

risk

Ischemic stroke

TOAST subtype

cerebral-hemorrhage

ABO blood group

genotype

infarction

disease

Author

Ellen Hanson

University of Gothenburg

Sara Karlsson

University of Gothenburg

Katarina Jood

University of Gothenburg

Staffan Nilsson

University of Gothenburg

Chalmers, Mathematical Sciences, Mathematical Statistics

Christian Blomstrand

University of Gothenburg

Christina Jern

University of Gothenburg

Thrombosis Research

0049-3848 (ISSN)

Vol. 130 3 339-342

Subject Categories

Neurology

DOI

10.1016/j.thromres.2012.03.016

PubMed

22482829

More information

Created

10/7/2017