Nano Hydroxyapatite-coated Implants Improve Bone Nanomechanical Properties
Journal article, 2012

Nanostructure modification of dental implants has long been sought as a means to improve osseointegration through enhanced biomimicry of host structures. Several methods have been proposed and demonstrated for creating nanotopographic features; here we describe a nanoscale hydroxyapatite (HA)-coated implant surface and hypothesize that it will hasten osseointegration and improve its quality relative to that of non-coated implants. Twenty threaded titanium alloy implants, half prepared with a stable HA nanoparticle surface and half grit-blasted, acid-etched, and heat-treated (HT), were inserted into rabbit femurs. Pre-operatively, the implants were morphologically and topographically characterized. After 3 weeks of healing, the samples were retrieved for histomorphometry. The nanomechanical properties of the surrounding bone were evaluated by nanoindentation. While both implants revealed similar bone-to-implant contact, the nanoindentation demonstrated that the tissue quality was significantly enhanced around the HA-coated implants, validating the postulated hypothesis.

histology

surfaces

modulus

dogs

calcium phosphate

titanium

nanostructures

biomechanics

tissue

dental implants

mechanical-properties

mineral-content

topography

osseointegration

Author

Ryo Jimbo

Malmö university

Paulo G Coelho

New York University

M. S. Bryington

Ohio State University

M. Baldassarri

New York University

N. Tovar

New York University

F Currie

Promimic AB

Mariko Hayashi

Malmö university

M. N. Janal

New York University

Martin Andersson

Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry

Daisuke Ono

Nagasaki University

Stefan Vandeweghe

Ghent university

Malmö university

Ann Wennerberg

Malmö university

Journal of Dental Research

0022-0345 (ISSN)

Vol. 91 12 1172-1177

Subject Categories

Dentistry

DOI

10.1177/0022034512463240

More information

Latest update

9/6/2018 1