Chemical Analysis of Single Cells
Review article, 2013
In this Review, we provide an overview of methods developed
for chemical analysis of single cells over the last two years.
Many biological systems contain an ensemble of cells with
heterogeneous chemistry; therefore, it is important to analyze
them on an individual basis in order to elucidate the role each cell
plays in the function of these systems. In clinical diagnostics, the
development of extremely sensitive measurements, down to
single cells, may provide the best ability for diagnoses. Single cell
analysis has, in fact, been present for quite some time.
Investigators in life sciences consider the cell as the unit of life
and so the pursuit to quantify, image, and modulate the cell has
been ongoing for decades.
ion mass-spectrometry
living cells
fluorescent protein
oxygen
reactive
in-vivo
multifunctional pipette
neuroendocrine cells
sample preparation
scanning electrochemical microscopy
droplet microfluidics
Author
R. Trouillon
University of Gothenburg
Melissa Passarelli
University of Gothenburg
J. Wang
University of Gothenburg
Michael Kurczy
Chalmers, Chemical and Biological Engineering, Analytical Chemistry
Andrew Ewing
Chalmers, Chemical and Biological Engineering, Analytical Chemistry
Analytical Chemistry
0003-2700 (ISSN) 1520-6882 (eISSN)
Vol. 85 2 522-542Subject Categories
Analytical Chemistry
DOI
10.1021/ac303290s