Salt and oxidative stress tolerance in Debaryomyces hansenii and Debaryomyces fabryi
Journal article, 2013

We report the characterization of five strains belonging to the halotolerant highly related Debaryomyces hansenii/fabryi species. The analysis performed consisted in studying tolerance properties, membrane characteristics, and cation incell amounts. We have specifically investigated (1) tolerance to different chemicals, (2) tolerance to osmotic and salt stress, (3) tolerance and response to oxidative stress, (4) reactive oxygen species (ROS) content, (5) relative membrane potential, (6) cell volume, (7) K+ and Na+ ion content, and (8) membrane fluidity. Unexpectedly, no direct relationship was found between one particular strain, Na+ content and its tolerance to NaCl or between its ROS content and its tolerance to H2O2. Results show that, although in general, human origin D.fabryi strains were more resistant to oxidative stress and presented shorter doubling times and smaller cell volume than food isolated D.hansenii ones, strains belonging to the same species can be significantly different. Debaryomyces fabryi CBS1793 strain highlighted for its extremely tolerant behavior when exposed to the diverse stress factors studied.

ripened cheeses

saccharomyces-cerevisiae cells

ROS content

membrane fluidity

stress tolerance

membrane fluidity






hemiascomycetous yeasts



sodium content


C. Michan

Universidad de Cordoba

Jose Luis Martinez Ruiz

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

M. C. Alvarez

Universidad de Cordoba

M. Turk

University of Ljubljana

H. Sychrova

Czech Academy of Sciences

J. Ramos

Universidad de Cordoba

FEMS Yeast Research

1567-1356 (ISSN) 1567-1364 (eISSN)

Vol. 13 2 180-188

Subject Categories

Chemical Sciences



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