Functional Mannose-Binding Lectin Haplotype Variants are Associated with Alzheimer's Disease
Journal article, 2013

Mannan-Binding lectin (MBL) is a serum lectin and an important constituent of the innate immune system. Processes linked to the innate immune response have previously been implicated in Alzheimer's disease (AD). MBL is associated with blood vessels in the brain and AD patients demonstrate lower MBL levels in the cerebrospinal fluid compared to controls. We investigated six single nucleotide polymorphisms, linked to MBL deficiency, in the corresponding MBL2 gene in AD patients and controls. Two MBL2 haplotypes, LXP and LYQ, were significantly associated with AD risk (OR = 1.6, p = 0.01 and OR = 1.5, p = 0.02, respectively). The present study is the first investigating MBL2 genotypes and haplotypes in relation to AD. Our findings support that the MBL2 gene impact the disease risk.


Annica Sjölander

University of Gothenburg

L. Minthon

Lund University

L. Nuytinck

Ghent university

E. Vanmechelen


Kaj Blennow

University of Gothenburg

Staffan Nilsson

University of Gothenburg

Chalmers, Mathematical Sciences, Mathematical Statistics

Journal of Alzheimers Disease

1387-2877 (ISSN)

Vol. 35 1 121-127

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