A possible association between panic disorder and a polymorphism in the preproghrelin gene
Journal article, 2013

The aim of the study was to investigate whether polymorphisms in the preproghrelin gene are associated with anxiety disorders, such as panic disorder, in humans. Panic disorder is a severe anxiety disorder, characterized by sudden attacks of intense fear or anxiety in combination with somatic symptoms. The preproghrelin gene codes for two gut-derived circulating peptides that have been linked to anxiety-like behaviour in rodents: ghrelin (an orexigenic, pro-obesity hormone) and obestatin. In the present study, we genotyped three missense mutations in the preproghrelin gene in 215 patients suffering from panic disorder and in 451 controls. The A allele of the rs4684677 polymorphism was significantly associated with panic disorder, while there were no significant associations with the two other polymorphisms studied. We conclude that the rs4684677 (Gln90Leu) polymorphism in the preproghrelin gene may be associated with increased risk of panic disorder. It will be important to confirm these findings in additional panic disorder patient groups.

Gln90Leu

Ghrelin

Obestatin

Anxiety

rs4684677

SNP

Panic disorder

Author

Caroline Hansson

University of Gothenburg

Kristina Annerbrink

University of Gothenburg

Staffan Nilsson

Chalmers, Mathematical Sciences, Mathematical Statistics

University of Gothenburg

Jessica Bah

University of Gothenburg

Marie Olsson

University of Gothenburg

Christer Allgulander

Karolinska Institutet

Sven Andersch

University of Gothenburg

I. Sjodin

Linköping University

Elias Eriksson

University of Gothenburg

Suzanne L. Dickson

University of Gothenburg

Psychiatry Research

0165-1781 (ISSN) 18727123 (eISSN)

Vol. 206 1 22-25

Subject Categories

Psychiatry

DOI

10.1016/j.psychres.2012.09.051

PubMed

23084284

More information

Latest update

2/28/2018