SNPs within the GH-signaling pathway are associated with the early IGF1 response to GH replacement therapy in GHD adults.
Journal article, 2014
GH-deficient (GHD) adults have reduced serum concentrations of IGF1. GH replacement therapy increases serum IGF1 concentrations, but the interindividual variation in treatment response is large and likely influenced by genetic factors. This study was designed to test the hypothesis that single-nucleotide polymorphisms (SNPs) in genes within the GH signaling pathway influence the serum IGF1 response to GH replacement.
Author
Camilla A M Glad
University of Gothenburg
Edna J L Barbosa
University of Gothenburg
Helena Filipsson Nyström
University of Gothenburg
Lena M S Carlsson
University of Gothenburg
Staffan Nilsson
Chalmers, Mathematical Sciences, Mathematical Statistics
University of Gothenburg
Anna G Nilsson
University of Gothenburg
Per-Arne Svensson
University of Gothenburg
Gudmundur Johannsson
University of Gothenburg
European Journal of Endocrinology
08044643 (ISSN) 1479683X (eISSN)
Vol. 170 1 101-7Subject Categories
Other Medical and Health Sciences
DOI
10.1530/EJE-13-0685
PubMed
24114431