SNPs within the GH-signaling pathway are associated with the early IGF1 response to GH replacement therapy in GHD adults.
Journal article, 2014

GH-deficient (GHD) adults have reduced serum concentrations of IGF1. GH replacement therapy increases serum IGF1 concentrations, but the interindividual variation in treatment response is large and likely influenced by genetic factors. This study was designed to test the hypothesis that single-nucleotide polymorphisms (SNPs) in genes within the GH signaling pathway influence the serum IGF1 response to GH replacement.


Camilla A M Glad

University of Gothenburg

Edna J L Barbosa

University of Gothenburg

Helena Filipsson Nyström

University of Gothenburg

Lena M S Carlsson

University of Gothenburg

Staffan Nilsson

Chalmers, Mathematical Sciences, Mathematical Statistics

University of Gothenburg

Anna G Nilsson

University of Gothenburg

Per-Arne Svensson

University of Gothenburg

Gudmundur Johannsson

University of Gothenburg

European Journal of Endocrinology

08044643 (ISSN) 1479683X (eISSN)

Vol. 170 1 101-7

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