The Effect of Hydroxyapatite Nanocrystals on Osseointegration of Titanium Implants: An In Vivo Rabbit Study
Journal article, 2014

Osseointegration is dependent on implant surface characteristics, including surface chemistry and topography. The presence of nanosized calcium phosphates on the implant surface is interesting to investigate since they affect both the nanotopography and surface chemistry, forming a bone mineral resembling surface. In this work, the osseointegration of titanium implants with and without the presence of hydroxyapatite (HA) nanocrystals has been evaluated in vivo. The integration was examined using removal torque measurements and real-time polymerase chain reaction (RT-PCR) analysis. The study was performed using two healing time points, 3 and 12 weeks. The results showed that the torque needed to remove the implants was insignificant between the non- and HA-coated implants, both at weeks 3 and 12. The RT-PCR, however, showed significant differences for osteoblast, osteoclast, and proinflammation markers when HA nanocrystals were present.


Karin Breding

Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry

Ryo Jimbo

Malmö university

Mariko Hayashi

Malmö university

Y. Xue

University of Bergen

K. Mustafa

University of Bergen

Martin Andersson

Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry

International Journal of Dentistry

1687-8728 (ISSN) 1687-8736 (eISSN)

Vol. 2014 (article id) 171305- 171305

Subject Categories

Chemical Sciences



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