Multivariate evaluation of doxorubicin surface-enhanced Raman spectra.
Journal article, 2001
Multivariate evaluation of surface-enhanced Raman spectra of doxorubicin in plasma was performed. In a principal component analysis (PCA) all spectral features were modelled into three principal components. The major variation of the data was shown to be the variation of doxorubicin Raman signal together with the doxorubicin fluorescence, whereas the variation due to plasma was of minor importance. It was also shown that the surface-enhanced Raman scattering (SERS) measurements were independent on such factors as measurement occasion and silver colloids. The presented results show that with some improvements, quantification of doxorubicin directly in plasma could be possible.
Multivariate Analysis
Antineoplastic
Computer-Assisted
blood
Spectrum Analysis
Raman
Principal Component Analysis
chemistry
blood
Signal Processing
chemistry
Doxorubicin
chemistry
Cattle
Plasma
Antibiotics
Animals
Author
[Person 2f2fe351-28be-47c1-a415-b63ce10e1f57 not found]
Chalmers, Department of Chemistry and Bioscience
[Person 33c294f4-4f45-47fd-b388-557c67141c53 not found]
Chalmers, Department of Chemistry and Bioscience, Analytical and Marine Chemistry
[Person d9513a94-4074-4a65-b2ee-73803ddcfb88 not found]
[Person 862ede00-434e-4617-a58a-843e0987981e not found]
[Person c65f32d7-6c79-4d54-885a-d46b14f85373 not found]
University of Gothenburg
[Person c6802b76-7e4c-4ce9-b0b8-c3e1f21dc469 not found]
University of Gothenburg
[Person 91713fd0-acab-485d-bec2-bcc46f459c03 not found]
University of Gothenburg
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
1386-1425 (ISSN)
Vol. 57 9 1907-15Subject Categories
Other Basic Medicine
PubMed
11506043