Elevated antibody reactivity to measles virus Ncore protein among patients with multiple sclerosis and their healthy siblings with intrathecal oligoclonal immunoglobulin G production
Journal article, 2014

Patients with multiple sclerosis (MS) and their healthy siblings with the MS oligoclonal bands (OCB) trait, (a hyperimmune condition in form of two or more CSF enriched OCBs) harbor in cerebrospinal fluid (CSF) and serum elevated immunoglobulin G (IgG) titers against measles crude whole-cell antigen. The underlying mechanism resulting in the increased IgG antibody reactivity to measles remains unclear. The response may represent specific IgG reactivity to measles antigens or unspecific auto-antibodies targeting cellular components in the crude whole virus antigens commonly used in detection assays.

likvor

mässlingvirus

oligoklonala band

antikroppar

multipel skleros

MS OCB trait

Author

Linn Persson

University of Gothenburg

Sonia Longhi

Aix Marseille Université

Johanna Enarsson

University of Gothenburg

Oluf Andersen

University of Gothenburg

Sara Haghighi

University of Gothenburg

Staffan Nilsson

University of Gothenburg

Chalmers, Mathematical Sciences, Mathematical Statistics

Martin Lagging

University of Gothenburg

Maria Johansson

University of Gothenburg

Tomas Bergström

University of Gothenburg

Journal of Clinical Virology

1386-6532 (ISSN)

Vol. 61 1 107-112

Subject Categories

Clinical Medicine

Neurology

Areas of Advance

Life Science Engineering

DOI

10.1016/j.jcv.2014.06.011

More information

Latest update

4/4/2018 6