Astatine-211 labeling: a study towards automatic production of astatinated antibodies
Journal article, 2015
Targeted alpha therapy is especially interesting for therapy of microscopic cancer tumors due to short path length and high linear energy transfer of the alpha particles. One of the most promising nuclides for targeted alpha therapy is At-211. To facilitate larger clinical studies using At-211, the current manual synthesis of radiolabeled antibodies would benefit from being transferred into an automated method. In this work, successful modifications of the manual synthesis have been performed in order to adapt it to automation. The automatic synthesis has also been tested using the modified synthesis method.
CANCER
Chemistry
Chemistry
Nuclear Science &
Inorganic & Nuclear
AT-211-LABELED ANTIBODIES
Radiopharmaceutical module
NUDE-MICE
Immunoconjugates
Antibodies
At-211
ALPHA-RADIOIMMUNOTHERAPY
Analytical
Technology
Labeling
Author
Emma Aneheim
University of Gothenburg
Holger Jensen
Per Albertsson
University of Gothenburg
Sture Lindegren
University of Gothenburg
Journal of Radioanalytical and Nuclear Chemistry
0236-5731 (ISSN) 1588-2780 (eISSN)
Vol. 303 1 979-983Subject Categories
Radiology, Nuclear Medicine and Medical Imaging
DOI
10.1007/s10967-014-3561-8