Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
Paper in proceedings, 2015

The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.


Murillo L. Martins

São Paulo State University (UNESP)

Niels Bohr Institute

A. Orecchini

Institut Laue-Langevin

University of Perugia

Luis Aguilera Medina

Chalmers, Applied Physics, Condensed Matter Physics

Juergen Eckert

University of South Florida

J.P. Embs

Paul Scherrer Institut

Aleksandar Matic

Chalmers, Applied Physics, Condensed Matter Physics

M.J. Saeki

São Paulo State University (UNESP)

Heloisa N. Bordallo

Niels Bohr Institute

EPJ Web of Conferences

21016275 (ISSN) 2100014X (eISSN)

Vol. 83 Art. no. 02011- 02011

Subject Categories

Condensed Matter Physics



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3/2/2020 1