No support for premature central nervous system aging in HIV-1 when measured by cerebrospinal fluid phosphorylated tau (p-tau)
Journal article, 2016

The prevalence of neurocognitive deficits are reported to be high in HIV-1 positive patients, even with suppressive antiretroviral treatment, and it has been suggested that HIV can cause accelerated aging of the brain. In this study we measured phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) as a potential marker for premature central nervous system (CNS) aging. P-tau increases with normal aging but is not affected by HIV-associated neurocognitive disorders.


Jan Jessen Krut

University of Gothenburg

R.W. Price

University of California

Henrik Zetterberg

University of Gothenburg

Dietmar Fuchs

Medical University of Innsbruck

Lars Hagberg

University of Gothenburg

Aylin Yilmaz

University of Gothenburg

Paola Cinque

IRCCS San Raffaele Scientific Institute

Staffan Nilsson

University of Gothenburg

Chalmers, Mathematical Sciences, Mathematical Statistics

Magnus Gisslén

University of Gothenburg


2150-5594 (ISSN) 2150-5608 (eISSN)

Vol. 8 5 599-604

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