Drug delivery from hydrogels: A general framework for the release modeling
Journal article, 2017

The controlled delivery of drugs, including siRNAs, can be effectively obtained using Hydrogel- Based Drugs Delivery Systems (HB-DDSs). Successful design of HB-DDSs requires the knowledge of the mechanisms that influence drug release. The modeling of the physical phenomena involved could help in the development and optimization of HB-DDS, sensibly reducing the time and costs required by a trial-and-error procedures. The modeling is rather complex because of the presence of several, synergistic and competing, transport phenomena. In this work a general framework useful for modeling the HB-DDS has been derived and it is proposed, coupling and homogenizing the literature models. It is shown that all of them can be traced back to two different approaches: multiphasic models and multicomponent mixture models. In the first one the hydrogel is seen as constituted by different phases, the behavior of each one being described by their own mass and momentum conservation equations. In the second approach, the hydrogel is considered as made of one phase composed by several components.

Hydrogels

siRNAs

Mathematical modeling

Controlled drug delivery

Author

Diego Caccavo

University of Salerno

Sara Cascone

University of Salerno

Gaetano Lamberti

University of Salerno

Anna Angela Barba

University of Salerno

Anette Larsson

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry, Pharmaceutical Technology

Current Drug Delivery

1567-2018 (ISSN)

Vol. 14 2 179-189

Subject Categories

Pharmaceutical Sciences

Areas of Advance

Production

Materials Science

DOI

10.2174/1567201813666160808102106

More information

Latest update

10/16/2018