Differential associations of systolic and diastolic time rate of blood pressure variation with carotid atherosclerosis and plaque echogenicity
Journal article, 2017

In the current study, the authors sought to assess whether the time rate of systolic and diastolic blood pressure variation is associated with advanced subclinical stages of carotid atherosclerosis and plaque echogenicity assessed by gray scale median. The authors recruited 237 consecutive patients with normotension and hypertension who underwent 24-hour ambulatory blood pressure monitoring and carotid artery ultrasonography. There was an independent association between low 24-hour systolic time rate and increased echogenicity of carotid plaques (adjusted odds ratio for highest vs lower tertiles of gray scale median, 0.470; 95% confidence interval, 0.245-0.902 [P = .023]). Moreover, increased nighttime diastolic time rate independently correlated with the presence (adjusted odds ratio, 1.328; P = .015) and number of carotid plaques (adjusted odds ratio, 1.410; P = .003). These results indicate differential associations of the systolic and diastolic components of time rate of blood pressure variation with the presence, extent, and composition of carotid plaques and suggest that when blood pressure variation is assessed, both components should be considered.



intima-media thickness




hypertensive patients

Cardiovascular System & Cardiology

european lacidipine



A. Kolyviras

University of Athens

E. Manios

University of Athens

G. Georgiopoulos

University of Athens

F. Michas

University of Athens

Tomas Gustavsson

Chalmers, Signals and Systems, Signal Processing and Biomedical Engineering

E. Papadopoulou

University of Athens

L. Ageliki

University of Athens

J. Kanakakis

University of Athens

C. Papamichael

University of Athens

G. Stergiou

University of Athens

N. Zakopoulos

University of Athens

K. Stamatelopoulos

University of Athens

Journal of Clinical Hypertension

1524-6175 (ISSN)

Vol. 19 11 1070-1077

Areas of Advance

Building Futures (2010-2018)

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Clinical Medicine

Other Medical and Health Sciences

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Basic sciences



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