21-Deoxycortisone (17α-hydroxy-4-pregnene-3,11,20-trione)
Journal article, 2005

The title compound, C21H28O4, a synthetic glucocorticoid, crystallizes with a single molecule in the asymmetric unit. Ring A is almost in a half-chair conformation, rings B and C are almost in chair conformations, and ring D is between a twist and a 13β-envelope conformation. The A/B ring junction is quasi-trans, whereas the B/C and C/D ring junctions both approach trans characteristics. The molecule as a whole is slightly convex towards the β side, with an angle of 9.60(2)° between the C10-C19 and C13-C18 vectors. Molecular-packing and hydrogen-bonding (both intra- and intermolecular) interactions play a major role in the structural association of the compound.


X-ray diffraction


Raja Dey

Chalmers, Chemical and Biological Engineering, Molecular Biotechnology

Vratislav Langer

Chalmers, Chemical and Biological Engineering, Environmental Inorganic Chemistry

P. Roychowdhury

S. Roychowdhury

M.G.B. Drew

Acta Crystallographica Section C: Crystal Structure Communications

0108-2701 (ISSN) 1600-5759 (eISSN)

Vol. C61 4 o201-o203

Subject Categories

Chemical Sciences

Organic Chemistry

More information