A comprehensive screen for SNP associations on chromosome region 5q31-33 in Swedish/Norwegian celiac disease families.
Journal article, 2007

Celiac disease (CD) is a gluten-induced enteropathy, which results from the interplay between environmental and genetic factors. There is a strong human leukocyte antigen (HLA) association with the disease, and HLA-DQ alleles represent a major genetic risk factor. In addition to HLA-DQ, non-HLA genes appear to be crucial for CD development. Chromosomal region 5q31–33 has demonstrated linkage with CD in several genome-wide studies, including in our Swedish/Norwegian cohort. In a European meta-analysis 5q31–33 was the only region that reached a genome-wide level of significance except for the HLA region. To identify the genetic variant(s) responsible for this linkage signal, we performed a comprehensive single nucleotide polymorphism (SNP) association screen in 97 Swedish/Norwegian multiplex families who demonstrate linkage to the region. We selected tag SNPs from a 16 Mb region representing the 95% confidence interval of the linkage peak. A total of 1404 SNPs were used for the association analysis. We identified several regions with SNPs demonstrating moderate single- or multipoint associations. However, the isolated association signals appeared insufficient to account for the linkage signal seen in our cohort. Collective effects of multiple risk genes within the region, incomplete genetic coverage or effects related to copy number variation are possible explanations for our findings.

celiac disease

5q31–33

autoimmunity

HLA

genetic association

Author

silja amundsen

University of Oslo

Svetlana Adamovic

University of Gothenburg

Åsa Hellqvist

University of Gothenburg

Staffan Nilsson

Chalmers, Mathematical Sciences, Mathematical Statistics

University of Gothenburg

Audur Gudjonsdottir

University of Gothenburg

Henry Ascher

University of Gothenburg

Johan Ek

Buskerud Central Hospital

Kristina Larsson

Uppsala University

Jan Wahlström

University of Gothenburg

Benedicte Lie

Rikshospitalet-Radiumhospitalet HF

Ludvig M Sollid

Rikshospitalet-Radiumhospitalet HF

University of Oslo

Åsa Torinsson Naluai

University of Gothenburg

European Journal of Human Genetics

1018-4813 (ISSN)

Vol. 15 9 980-987

Subject Categories

Microbiology in the medical area

DOI

10.1038/sj.ejhg.5201870

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