Identification of genes predominantly expressed in human macrophages
Journal article, 2004

Identification of cell and tissue specific genes may provide novel insights to signaling systems and functions. Macrophages play a key role in many diseases including atherosclerosis. Using DNA microarrays we compared the expression of approximately 10,000 genes in 56 human tissues and identified 23 genes with predominant expression in macrophages. The identified genes include both genes known to be macrophage specific and genes previously not well described in this cell type. Tissue distribution of two genes, liver X receptor (LXR) alpha and interleukin-1 receptor antagonist (IL1RN), was verified by real-time RT-PCR. We conclude that comparison of expression profiles from a large number of tissues can be used to identify genes that are predominantly expressed in certain tissues. Identification of novel macrophage specific genes may increase our understanding of the role of this cell in different diseases.

Oligonucleotide Array Sequence Analysis


Tissue Distribution

Interleukin 1 Receptor Antagonist Protein

Cytoplasmic and Nuclear/*genetics




DNA-Binding Proteins


Per Anders Svensson

University of Gothenburg

Daniel Hägg

University of Gothenburg

Margareta Jernås

University of Gothenburg

Mikael Englund

University of Gothenburg

Lillemor Mattsson Hultén

University of Gothenburg

Bertil Ohlsson

University of Gothenburg

Johannes Hulthe

University of Gothenburg

Olov Wiklund

University of Gothenburg

Björn Carlsson

University of Gothenburg

Björn Fagerberg

University of Gothenburg

Lena M S Carlsson

University of Gothenburg


Vol. 177 2 287-90

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