Analysis of clinical data to determine the minimum number of sensors required for adequate skin temperature monitoring of superficial hyperthermia treatments
Journal article, 2018

Purpose: Tumor response and treatment toxicity are related to minimum and maximum tissue temperatures during hyperthermia, respectively. Using a large set of clinical data, we analyzed the number of sensors required to adequately monitor skin temperature during superficial hyperthermia treatment of breast cancer patients. Methods: Hyperthermia treatments monitored with >60 stationary temperature sensors were selected from a database of patients with recurrent breast cancer treated with re-irradiation (23 × 2 Gy) and hyperthermia using single 434 MHz applicators (effective field size 351–396 cm2). Reduced temperature monitoring schemes involved randomly selected subsets of stationary skin sensors, and another subset simulating continuous thermal mapping of the skin. Temperature differences (ΔT) between subsets and complete sets of sensors were evaluated in terms of overall minimum (Tmin) and maximum (Tmax) temperature, as well as T90 and T10. Results: Eighty patients were included yielding a total of 400 hyperthermia sessions. Median ΔT was 50 sensors were used. Subsets of 50 sensors were used. Thermal profiles (8–21 probes) yielded a median ΔT < 0.01 °C for T90 and Tmax, with a 95%CI of −0.2 °C and 0.4 °C, respectively. The detection rate of Tmax≥43 °C is ≥85% while using >50 stationary sensors or thermal profiles. Conclusions: Adequate coverage of the skin temperature distribution during superficial hyperthermia treatment requires the use of >50 stationary sensors per 400 cm2applicator. Thermal mapping is a valid alternative.

radiation therapy

quality assurance

thermal dosimetry

temperature monitoring

Hyperthermia

Author

A. Bakker

University of Amsterdam

Rebecca Holman

University of Amsterdam

Dario B. Rodrigues

Thomas Concrete Group

Hana Dobsicek Trefna

Chalmers, Electrical Engineering, Signalbehandling och medicinsk teknik, Biomedical Electromagnetics

P. R. Stauffer

Thomas Concrete Group

Geertjan van Tienhoven

University of Amsterdam

Coen R.N. Rasch

University of Amsterdam

Hans Crezee

University of Amsterdam

International Journal of Hyperthermia

0265-6736 (ISSN) 1464-5157 (eISSN)

Vol. 34 7 910-917

Subject Categories

Surgery

Medical Laboratory and Measurements Technologies

Cancer and Oncology

DOI

10.1080/02656736.2018.1466000

More information

Latest update

9/13/2018