A Deep Learning Approach to MR-less Spatial Normalization for Tau PET Images
Paper in proceeding, 2019

The procedure of aligning a positron emission tomography (PET) image with a common coordinate system, spatial normalization, typically demands a corresponding structural magnetic resonance (MR) image. However, MR imaging is not always available or feasible for the subject, which calls for enabling spatial normalization without MR, MR-less spatial normalization. In this work, we propose a template-free approach to MR-less spatial normalization for [18F]flortaucipir tau PET images. We use a deep neural network that estimates an aligning transformation from the PET input image, and outputs the spatially normalized image as well as the parameterized transformation. In order to do so, the proposed network iteratively estimates a set of rigid and affine transformations by means of convolutional neural network regressors as well as spatial transformer layers. The network is trained and validated on 199 tau PET volumes with corresponding ground truth transformations, and tested on two different datasets. The proposed method shows competitive performance in terms of registration accuracy as well as speed, and compares favourably to previously published results.

Author

Jennifer Alvén

Chalmers, Electrical Engineering, Signal Processing and Biomedical Engineering

Kerstin Heurling

University of Gothenburg

Ruben Smith

Lund University

Olof Strandberg

Lund University

Michael Schöll

University of Gothenburg

Oskar Hansson

Lund University

Fredrik Kahl

Chalmers, Electrical Engineering, Signal Processing and Biomedical Engineering

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

03029743 (ISSN) 16113349 (eISSN)

Vol. 11765 LNCS 355-363
9783030322441 (ISBN)

International Conference on Medical Image Computing and Computer-Assisted Intervention
Shenzhen, China,

Areas of Advance

Information and Communication Technology

Life Science Engineering (2010-2018)

Subject Categories

Computer Vision and Robotics (Autonomous Systems)

Medical Image Processing

DOI

10.1007/978-3-030-32245-8_40

More information

Latest update

7/22/2024