Kinetic aspects of the interplay of cancer and the immune system
Book chapter, 2020

The understanding of the interplay between cancer and the immune system is still limited. Herein, I focus on two aspects of this interplay. First, I propose a kinetic model describing the likely role of the immune system in the lifetime risk of cancer at the level of the whole human population. For each tissue, the risk is predicted to be influenced by the heterogeneity of the population and to depend exponentially on time. The expression for the risk does not, however, depend explicitly on the total number of divisions of the corresponding stem cells. For this reason, the correlation with the latter number can only be indirect. Second, using another kinetic framework, I describe how the growth of a few tumors can depend on their interaction via the immune system. The analysis shows that depending on specific details, the tumors of different sizes tend either to reach the same size or remain to be of different sizes.

Initiation

Tumor growth

Immune system

cancer

Lifetime risk

Author

Vladimir Zhdanov

Russian Academy of Sciences

Chalmers, Physics, Nano and Biophysics

The Physics of Cancer, Research Advances

229-242

Subject Categories

Biomedical Laboratory Science/Technology

Immunology in the medical area

Cancer and Oncology

Areas of Advance

Health Engineering

DOI

10.1142/9789811223495_0011

More information

Latest update

7/28/2021