Chemical modification of glycosaminoglycan polysaccharides
Review article, 2021

The linear anionic class of polysaccharides, glycosaminoglycans (GAGs), are critical throughout the animal kingdom for developmental processes and the maintenance of healthy tis-sues. They are also of interest as a means of influencing biochemical processes. One member of the GAG family, heparin, is exploited globally as a major anticoagulant pharmaceutical and there is a growing interest in the potential of other GAGs for diverse applications ranging from skin care to the treatment of neurodegenerative conditions, and from the treatment and prevention of microbial infection to biotechnology. To realize the potential of GAGs, however, it is necessary to develop effective tools that are able to exploit the chemical manipulations to which GAGs are susceptible. Here, the current knowledge concerning the chemical modification of GAGs, one of the principal approaches for the study of the structure-function relationships in these molecules, is reviewed. Some additional methods that were applied successfully to the analysis and/or processing of other carbohydrates, but which could be suitable in GAG chemistry, are also discussed.

Chemical modification

Glycosaminoglycans

Sulfation

Polysaccharides

Author

Lais C.G.F. Palhares

Federal University of Rio Grande do Norte

James A. London

University of Liverpool

Aleksandra Maria Kozlowski

Chalmers, Chemistry and Chemical Engineering, Chemical Technology, Forest Products and Chemical Engineering

Emiliano Esposito

Ronzoni Institute

Suely F. Chavante

Federal University of Rio Grande do Norte

Minghong Ni

Ronzoni Institute

Edwin A. Yates

University of Liverpool

Molecules

1420-3049 (ISSN)

Vol. 26 17 5211

Subject Categories

Chemical Process Engineering

Bioprocess Technology

Reliability and Maintenance

DOI

10.3390/molecules26175211

PubMed

34500644

More information

Latest update

9/13/2021