Electrochemical Sensing of Chlorpyrifos, a Carcinogen Responsible for Breast Cancer, in Milk and Plasma of Lactating Mothers
Journal article, 2023

In view of the increase in breast cancer cases at the global level, electrochemical sensing of the carcinogenic pesticide, chlorpyrifos (CPF) in breast milk is proposed. The determination is based on the nucleophilic substitution reaction of pralidoxime (PAM) with CPF. The proposed method offers a linear concentration range of 0.002 to 0.08 μmol/L. The limit of detection and limit of quantification was found to be 0.05×10−9 and 0.167×10−9M, respectively. The offered “unmodified edge plane pyrolytic graphite sensor” proved to be a better substrate than the earlier reported modified sensors. The limit of detection for the proposed method was found to be nearly fifty times lower than reported at modified electrodes. The interference study proved the adequate selectivity of the offered sensor. The sensor has good stability and reproducibility along with high sensitivity. The offered sensor is very useful for cancer hospitals, pesticide industries, and the study of environmental toxicity-related issues.

EPPG Sensor

Blood Plasma

Breast Milk

CPF

Breast Cancer

Author

Sunita Bishnoi

Vivekananda Global University

Ashutosh Sharma

Vivekananda Global University

Rahul Singhal

Malaviya National Institute of Technology Jaipur

Pankaj Gupta

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

Rajendra N. Goyal

Indian Institute of Technology

Electroanalysis

1040-0397 (ISSN) 1521-4109 (eISSN)

Vol. 35 2 e202200238

Subject Categories

Medical Laboratory and Measurements Technologies

Analytical Chemistry

Other Chemical Engineering

DOI

10.1002/elan.202200238

More information

Latest update

5/30/2024