Assessment of nanoliposomes loaded with daidzein for ameliorating diabetes in alloxan-induced mice: A promising nutraceutical approach
Journal article, 2023

The present study synthesized and evaluated the effects of nanoliposomes loaded daidzein (NLD) in diabetic mice induced by alloxan. Five groups of Balb-c mice were treated for 5 weeks (Group 1 and 2 referred to as normal and diabetic control receiving normal feed). Group 3 and 4 were diabetic mice receiving 50 and 100 mg/kg/BW NLD respectively. Group 5, diabetic mice, received the standard drug, Metformin, 250 mg/kg/BW per day orally. Results indicated that NLD significantly (p < 0.05) improved the final body weight, triglyceride (TG), total cholesterol (TC) concentrations, low-density lipoprotein cholesterol and malondialdehyde (MDA) levels and enhanced the high-density lipoprotein. Furthermore, NLD enhanced the expression of CAT and suppressed iNOS gene in the pancreas. The mRNA expression of GLUT2 and GLUT4 also showed increase in the diabetic mice. Findings demonstrated the potential of NLD as a nutraceutical for the prevention and/or treatment of diabetes without toxic side effects.

Drug delivery system

Phytogenics

Isoflavonoids

Nano-delivery systems

Encapsulation

Author

Negar Chalaki Rad

Islamic Azad University

Ehsan Karimi

Islamic Azad University

Homa Mahmoodzadeh Akherat

Islamic Azad University

Ehsan Oskoueian

Industrial and Mineral Research Center

Mohsen Zareian

Chalmers, Life Sciences, Food and Nutrition Science

Journal of Functional Foods

1756-4646 (ISSN)

Vol. 110 105848

Subject Categories

Endocrinology and Diabetes

DOI

10.1016/j.jff.2023.105848

More information

Latest update

1/2/2024 3