Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families
Journal article, 2008
The first genome-wide association study performed in a UK coeliac disease (CD) case-control cohort revealed association with a linkage disequilibrium block containing the KIAA1109/Tenr/IL2/IL21 genes. Also recently, an association with a non-synonymous polymorphism in Fcitalic gammaRIIa (CD32a) was reported in CD with an unusually strong P-value. We aimed to replicate the reported associations with the single nucleotide polymorphisms rs13119723 A>G and rs6822844 G>T in the KIAA1109/Tenr/IL2/IL21 region and rs1801274 G>A in the Fcitalic gammaRIIa gene in a family sample consisting of 325 Swedish/Norwegian families using the robust transmission disequilibrium test. The family sample used in this study included 100 families with two or more children affected by CD and 225 families with one affected child. We could confirm significant association between the polymorphisms rs13119723 A>G and rs6822844 G>T located in the KIAA1109/Tenr/IL2/IL21 region and CD (P-value 0.001 and 0.002, respectively). However, we found no association with the Fcitalic gammaRIIa rs1801274 G>A polymorphism (P-value=0.3). In conclusion, our results support the KIAA1109/Tenr/IL2/IL21 region as a true CD susceptibility region.
IL2
autoimmunity
IL21
FcRIIa
4q27
celiac
Author
Svetlana Adamovic
University of Gothenburg
silja amundsen
University of Oslo
Benedicte A Lie
Rikshospitalet-Radiumhospitalet HF
Audur Gudjonsdottir
Sahlgrenska University Hospital
Henry Ascher
Nordiska Hogskolan for folkhalsovetenskap
Sahlgrenska University Hospital
Johan Ek
Sykehuset Buskerud HF
David A van Heel
Queen Mary University of London
Staffan Nilsson
Chalmers, Mathematical Sciences, Mathematical Statistics
University of Gothenburg
Ludvig M Sollid
Rikshospitalet-Radiumhospitalet HF
University of Oslo
Åsa Torinsson Naluai
University of Gothenburg
Genes and Immunity
1466-4879 (ISSN) 1476-5470 (eISSN)
Vol. 9 4 364-367Subject Categories
Cell and Molecular Biology
DOI
10.1038/gene.2008.27