Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families
Journal article, 2008

The first genome-wide association study performed in a UK coeliac disease (CD) case-control cohort revealed association with a linkage disequilibrium block containing the KIAA1109/Tenr/IL2/IL21 genes. Also recently, an association with a non-synonymous polymorphism in Fcitalic gammaRIIa (CD32a) was reported in CD with an unusually strong P-value. We aimed to replicate the reported associations with the single nucleotide polymorphisms rs13119723 A>G and rs6822844 G>T in the KIAA1109/Tenr/IL2/IL21 region and rs1801274 G>A in the Fcitalic gammaRIIa gene in a family sample consisting of 325 Swedish/Norwegian families using the robust transmission disequilibrium test. The family sample used in this study included 100 families with two or more children affected by CD and 225 families with one affected child. We could confirm significant association between the polymorphisms rs13119723 A>G and rs6822844 G>T located in the KIAA1109/Tenr/IL2/IL21 region and CD (P-value 0.001 and 0.002, respectively). However, we found no association with the Fcitalic gammaRIIa rs1801274 G>A polymorphism (P-value=0.3). In conclusion, our results support the KIAA1109/Tenr/IL2/IL21 region as a true CD susceptibility region.








Svetlana Adamovic

University of Gothenburg

silja amundsen

University of Oslo

Benedicte A Lie

Rikshospitalet-Radiumhospitalet HF

Audur Gudjonsdottir

Sahlgrenska University Hospital

Henry Ascher

Nordiska Hogskolan for folkhalsovetenskap

Sahlgrenska University Hospital

Johan Ek

Sykehuset Buskerud HF

David A van Heel

Queen Mary University of London

Staffan Nilsson

Chalmers, Mathematical Sciences, Mathematical Statistics

University of Gothenburg

Ludvig M Sollid

Rikshospitalet-Radiumhospitalet HF

University of Oslo

Åsa Torinsson Naluai

University of Gothenburg

Genes and Immunity

1466-4879 (ISSN) 1476-5470 (eISSN)

Vol. 9 4 364-367

Subject Categories

Cell and Molecular Biology



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1/5/2021 1