Pharmacological treatment of osteopenia induced by gastrectomy or ovariectomy in young female rats.
Journal article, 2004

BACKGROUND: Both gastrectomy (GX) and ovariectomy (OVX) induce osteopenia in man and experimental animals. The present study addresses the question--can alendronate, estrogen or parathyroid hormone (PTH) be used to treat established GX- or OVX -evoked osteopenia? METHODS: Rats were GX-, OVX- or SHAM-operated 8 weeks before starting the treatment with drugs. Each group was then treated for 8 weeks with 50 microg/kg/day alendronate, 10 microg/kg/day estrogen or 75 microg/kg/day PTH(1-84); n = 8 rats/group. Peripheral Quantitative Computed Tomography (pQCT) was used to measure trabecular bone mineral density (BMD) and various cortical bone parameters. RESULTS: At killing, 16 weeks after surgery, GX and OVX rats had a greatly reduced trabecular BMD in the metaphysis of the distal femur (GX -44% and OVX -55%). Alendronate increased the trabecular BMD by 44% in GX rats and by 64% in OVX rats, while PTH increased it by 51% and 115%, respectively. However, estrogen increased the trabecular BMD in GX rats (35%), but not in OVX rats (15%, not significant). Cortical bone parameters were adversely (but moderately) affected by GX, but not by OVX or by treatment with the three drugs. INTERPRETATION: Alendronate, estrogen and PTH restored the trabecular bone loss in rats with an established GX-evoked osteopenia. In contrast, alendronate and PTH, but not estrogen, restored the trabecular bone loss after OVX. Hence, the mechanism underlying GX-evoked bone loss differs from that underlying OVX-evoked bone loss. The ability of alendronate, estrogen and PTH to reverse the GX-evoked osteopenia in the rat may be of clinical interest when dealing with bone loss in humans after GX.

pharmacology

Estrogens

Models

therapeutic use

Diphosphonates

pharmacology

therapeutic use

Alendronate

physiopathology

Hormones

Animals

therapeutic use

X-Ray Computed

drug therapy

etiology

therapeutic use

pharmacology

Rats

drug effects

Parathyroid Hormone

physiology

adverse effects

pharmacology

Ovariectomy

Gastrectomy

Bone Density

Female

Sprague-Dawley

Tomography

Rats

Metabolic

adverse effects

pharmacology

Animal

Bone Diseases

therapeutic use

Author

Niklas Andersson

University of Gothenburg

Vikas V Surve

Daisy Lehto-Axtelius

Kjell Andersson

Birgitta Ryberg

Claes Ohlsson

University of Gothenburg

Rolf Håkanson

Acta Orthopaedica Scandinavica

0001-6470 (ISSN) 1651-1964 (eISSN)

Vol. 75 201-9

Subject Categories

MEDICAL AND HEALTH SCIENCES

DOI

10.1080/00016470412331294465

PubMed

15180236