Oxygen radical production in leukocytes and disease severity in multiple sclerosis.
Journal article, 2009

This study investigated the relationship between the formation of NADPH oxidase-dependent oxygen radicals in peripheral blood leukocytes ('respiratory burst') and disease severity in patients with multiple sclerosis (MS). Oxygen radical production was induced by formyl-Met-Leu-Phe (fMLF), Trp-Lys-Tyr-Met-Val-Met-NH2 (WKYMVM) or phorbol myristate acetate (PMA) and was assessed by quantifying superoxide anion, i.e. the initial radical formed by the NADPH oxidase. Disease severity was evaluated using the Multiple Sclerosis Severity Score (MSSS). In patients with severe disease, the production of superoxide anion was significantly lower for all three inducers of radical formation (p=0.04-0.004). Our findings are supportive of a protective role of oxygen radicals in autoimmunity.

Severity

immunology

Reactive Oxygen Species

Immunology

immunology

Multiple Sclerosis

Phagocytes

Respiratory Burst

NADPH Oxidase

Leukocytes

Author

Natalia Mossberg

University of Gothenburg

Charlotta Movitz

University of Gothenburg

Kristoffer Hellstrand

University of Gothenburg

Tomas Bergström

University of Gothenburg

Staffan Nilsson

Chalmers, Mathematical Sciences, Mathematical Statistics

University of Gothenburg

Oluf Andersen

University of Gothenburg

Journal of neuroimmunology

1872-8421 (ISSN)

Vol. 213 1-2 131-134

Subject Categories

MEDICAL AND HEALTH SCIENCES

DOI

10.1016/j.jneuroim.2009.05.013

PubMed

19589606

More information

Created

10/7/2017