Jonas Hannestad

Temporary extension at Chalmers, Physics, Biological Physics

Every year there are approximately 10 million new cases of dementia worldwide. Today more than 45 million people are living with dementia, a figure that will almost double every 20 years. This increase is largely caused by an aging population and finding effective treatments is an ever-growing concern. The far most common form of dementia is Alzheimer’s disease, accounting for between 50 and 70% of the cases. As of today, there is no cure for Alzheimer’s disease and available treatments only offer a limited symptomatic relief. There is also a need for methods that allow diagnosis at earlier stages of the disease.In my research, I strive to elucidate the underlying molecular mechanisms behind Alzheimer’s disease. A better understanding of the processes that drive disease progression can hopefully lead to potential new means to treat and diagnose Alzheimer’s disease. My primary research focus lie in understanding the importance of the interaction between Alzheimer’s-associated peptides and proteins such as Amyloid-b and Tau with lipid membranes. I approach these challenges working with a broad focus ranging from studies of molecular distribution and co-localization in the brains of Alzheimer’s-affected mice to biophysical studies of protein-membrane interactions.To cover this wide range of perspectives I employ a diverse spectrum of experimental techniques, including imaging mass spectrometry (TOF-SIMS), fluorescence spectroscopy and microscopy (e.g. TIRF and TCSPC) and quartz crystal microbalance (QCM-D). In my research at the Division of Biological Physics and at RISE – Research Institutes of Sweden, I strive to elucidate the underlying molecular mechanisms behind Alzheimer’s disease. Every year there are approximately 10 million new cases of dementia worldwide. Today more than 45 million people are living with dementia, a figure that will almost double every 20 years. This increase is largely caused by an aging population and finding effective treatments is an ever-growing concern. The far most common form of dementia is Alzheimer’s disease, accounting for between 50 and 70% of the cases. As of today, there is no cure for Alzheimer’s disease and available treatments only offer a limited symptomatic relief. There is also a need for methods that allow diagnosis at earlier stages of the disease.A better understanding of the processes that drive disease progression can hopefully lead to potential new means to treat and diagnose Alzheimer’s disease. My primary research focus lie in understanding the importance of the interaction between Alzheimer’s-associated peptides and proteins such as Amyloid-b and Tau with lipid membranes. I approach these challenges working with a broad focus ranging from studies of molecular distribution and co-localization in the brains of Alzheimer’s-affected mice to biophysical studies of protein-membrane interactions.To cover this wide range of perspectives I employ a diverse spectrum of experimental techniques, including imaging mass spectrometry (TOF-SIMS), fluorescence spectroscopy and microscopy (e.g. TIRF and TCSPC) and quartz crystal microbalance (QCM-D).

Source: chalmers.se

Showing 14 publications

2018

Nanometer-scale molecular organization in lipid membranes studied by time-of-flight secondary ion mass spectrometry

Jonas Hannestad, Fredrik Höök, Peter Sjövall
Biointerphases. Vol. 13 (3)
Journal article
2018

Structure and Composition of Native Membrane Derived Polymer-Supported Lipid Bilayers

Hudson Pace, Jonas Hannestad, Antonious Armonious et al
Analytical Chemistry. Vol. 90 (21), p. 13065-13072
Journal article
2017

Site-selective immobilization of functionalized DNA origami on nanopatterned Teflon AF

Mehrnaz Shaali, Jakob Woller, Peter Johansson et al
Journal of Materials Chemistry C. Vol. 5 (30), p. 7637-7643
Journal article
2013

Multistep FRET and Nanotechnology

Bo Albinsson, Jonas Hannestad
FRET - Förster Resonance Energy Transfer: From Theory to Applications, p. 607-653
Book chapter
2013

Self-Assembled Nanoscale DNA-Porphyrin Complex for Artificial Light Harvesting

Jakob Woller, Jonas Hannestad, Bo Albinsson
Journal of the American Chemical Society. Vol. 135 (7), p. 2759-2768
Journal article
2013

Kinetics of Diffusion-Mediated DNA Hybridization in Lipid Monolayer Films Determined by Single-Molecule Fluorescence Spectroscopy

Jonas Hannestad, Ralf Brune, Ilja Czolkos et al
ACS Nano. Vol. 7 (1), p. 308-315
Journal article
2012

Functionalized DNA Nanostructures for Light Harvesting and Charge Separation

Bo Albinsson, Karl Börjesson, Jonas Hannestad
Coordination Chemistry Reviews. Vol. 256 (21-22), p. 2399-2413
Journal article
2011

Self-Assembled DNA-Based Fluorescence Waveguide with Selectable Output

Jonas Hannestad, S. R. Gerrard, T. Brown et al
Small. Vol. 7 (22), p. 3178-3185
Journal article
2010

UV-Dissipation Mechanisms in the Eumelanin Building Block DHICA

A. Huijser, A. Pezzella, Jonas Hannestad et al
ChemPhysChem. Vol. 11 (11), p. 2424-2431
Journal article
2009

Platform for Controlled Supramolecular Nano-Assembly

Ilja Czolkos, Jonas Hannestad, Aldo Jesorka et al
Nano Letters. Vol. 9 (6), p. 2482-2486
Journal article
2008

Self-assembled DNA photonic wire

Jonas Hannestad, Peter Sandin, Bo Albinsson
Nucleic acids symposium series (2004) (52), p. 685-
Journal article
2008

Self-Assembled DNA Photonic Wire for Long-Range Energy Transfer

Jonas Hannestad, Peter Sandin, Bo Albinsson
Journal of the American Chemical Society. Vol. 130 (47), p. 15889-15895
Journal article

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