Michaela Wenzel

Associate Professor at Chemical Biology

Michaela Wenzel is a microbiologist interested in antibiotic mechanisms of action and bacterial mechanisms of resistance. Her group uses fluorescence and electron microscopy together with proteomic and spectroscopic techniques to study the interaction of antimicrobial compounds with bacterial cells with a focus on the bacterial cell envelope. The goal is to provide a deeper fundamental understanding of how antibiotics interact with bacterial cells and use this knowledge to develop more sustainable antibiotics and novel antibacterial strategies.

Michaela is vice director of the Center for Antibiotic Resistance Research in Gotheburg (CARe).

Source: chalmers.se

Contact Details

Publications (20)
Projects (9)

Showing 20 publications

2024

Lipid phase separation impairs membrane thickness sensing by the <i>Bacillus subtilis</i> sensor kinase DesK

Margareth Sidarta, Ana I. Lorente Martin, Anuntxi Monsalve et al

Microbiology spectrum. Vol. 12 (6)

Journal article

Show project

2024

The Diverse Activities and Mechanisms of the Acylphloroglucinol Antibiotic Rhodomyrtone: Antibacterial Activity and Beyond

Rupa Rani, Gabriela Marino Righetto, Ann-Britt Schäfer et al

Antibiotics. Vol. 13 (10)

Review article

2024

Nature inspired unique antimicrobial peptides from Chilean marine sediments

Luisa Beyer, Ann-Britt Schäfer, Agustina Natalia Undabarrena Canusso et al

Journal of Peptide Science. Vol. 30 (2)

Other text in scientific journal

2024

Membrane depolarization kills dormant Bacillus subtilis cells by generating a lethal dose of ROS

Declan Alan Gray, Biwen Wang, Margareth Sidarta et al

Nature Communications. Vol. 15 (1)

Journal article

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2024

Mimicking Nonribosomal Peptides from the Marine Actinomycete Streptomyces sp. H-KF8 Leads to Antimicrobial Peptides

Luisa I. Beyer, Ann-Britt Schäfer, Agustina Undabarrena et al

ACS Infectious Diseases. Vol. 10 (1), p. 79-92

Journal article

2023

Tracking Global and Local Changes in Membrane Fluidity Through Fluorescence Spectroscopy and Microscopy

Madeleine Humphrey, Ireny Abdelmesseh Nekhala Abdelmesseh, Kathi Scheinpflug et al

Methods in Molecular Biology. Vol. 2601, p. 203-229

Book chapter

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2023

Dual Action of Eeyarestatin 24 on Sec-Dependent Protein Secretion and Bacterial DNA

Ann-Britt Schäfer, Maurice Steenhuis, Kin Ki Jim et al

ACS Infectious Diseases. Vol. 9 (2), p. 253-269

Journal article

2023

Design, Synthesis, Molecular Modeling, Biological Activity, and Mechanism of Action of Novel Amino Acid Derivatives of Norfloxacin

Ahmed M. Kamal El-sagheir, Ireny Abdelmesseh Nekhala Abdelmesseh, Mohammed K. Abd El-Gaber et al

ACS Omega. Vol. 8 (45), p. 43271-43284

Journal article

2023

N4-Substituted Piperazinyl Norfloxacin Derivatives with Broad-Spectrum Activity and Multiple Mechanisms on Gyrase, Topoisomerase IV, and Bacterial Cell Wall Synthesis

Ahmed M. Kamal El-Sagheir, Ireny Abdelmesseh Nekhala Abdelmesseh, Mohammed K. Abd El-Gaber et al

ACS Bio and Med Chem Au. Vol. 3 (6), p. 494-506

Journal article

2023

Rational design, synthesis, molecular modeling, biological activity, and mechanism of action of polypharmacological norfloxacin hydroxamic acid derivatives

Ahmed M. Kamal El-sagheir, Ireny Abdelmesseh Nekhala Abdelmesseh, Mohammed K. Abd El-Gaber et al

RSC Medicinal Chemistry. Vol. 14 (12), p. 2593-2610

Journal article

2022

Roles of Bacterial Mechanosensitive Channels in Infection and Antibiotic Susceptibility

Margareth Sidarta, Luna Baruah, Michaela Wenzel

Pharmaceuticals. Vol. 15 (7)

Review article

2022

SepF supports the recruitment of the DNA translocase SftA to the Z-ring

Terrens N.V. Saaki, Zihao Teng, Michaela Wenzel et al

Molecular Microbiology. Vol. 117 (5), p. 1263-1274

Journal article

2021

Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation

Christoph H.R. Senges, Jennifer J. Stepanek, Michaela Wenzel et al

Antimicrobial Agents and Chemotherapy. Vol. 65 (1)

Journal article

2021

A flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline

Michaela Wenzel, Marien P. Dekker, Biwen Wang et al

Communications Biology. Vol. 4 (1), p. 306-306

Journal article

2021

Control of septum thickness by the curvature of SepF polymers

Michaela Wenzel, Ilkay N. Celik Gulsoy, Yongqiang Gao et al

Proceedings of the National Academy of Sciences of the United States of America. Vol. 118 (2)

Journal article

2020

Do we really understand how antibiotics work?

Michaela Wenzel

Future Microbiology. Vol. 15 (14), p. 1307-1311

Review article

2020

More than a pore: A current perspective on the in vivo mode of action of the lipopeptide antibiotic daptomycin

Declan Alan Gray, Michaela Wenzel

Antibiotics. Vol. 9 (1)

Review article

2020

A How-To Guide for Mode of Action Analysis of Antimicrobial Peptides

Ann-Britt Schäfer, Michaela Wenzel

Frontiers in cellular and infection microbiology. Vol. 10

Review article

2020

Multitarget Approaches against Multiresistant Superbugs

Declan Alan Gray, Michaela Wenzel

ACS Infectious Diseases. Vol. 6 (6), p. 1346-1365

Review article

Show project

2019

Membranaktive Antibiotika: neue Mechanismen gegen ein altbekanntes Ziel

Michaela Wenzel

BioSpektrum. Vol. 25 (6), p. 683-683

Journal article

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Showing 9 research projects

2023–2025

New strategies for breaking intrinsic antibiotic resistance