Michaela Wenzel
I am a molecular microbiologist and bacterial cell biologist with a background in multi-omics and advanced single-cell fluorescence microscopy. My main research interest is the interaction of bacteria and fungi with stress factors in their environment, in particular antibiotics and other antimicrobials. I am trying to understand how these factors affect microbial physiology and how cells adapt and become tolerant or resistant to them. I am interested in both fundamental research and developing new therapeutic strategies. My lab generates large amounts of omics and microscopy data with considerable mechanistic depth and uses AI for data-driven antibiotic design and development.
Showing 56 publications
Antibacterial Activity of Solid-Supported Gold Nanorods Combined with Antimicrobial Peptides
Expanding the DNA damaging potential of artificial metallo-nucleases with click chemistry
Contribution of the Bacillus subtilis ytrGABCDEF operon to antibiotic stress adaptation
The last resort antibiotic daptomycin exhibits two independent antibacterial mechanisms of action
Nature inspired unique antimicrobial peptides from Chilean marine sediments
Membrane depolarization kills dormant Bacillus subtilis cells by generating a lethal dose of ROS
Dual Action of Eeyarestatin 24 on Sec-Dependent Protein Secretion and Bacterial DNA
Roles of Bacterial Mechanosensitive Channels in Infection and Antibiotic Susceptibility
SepF supports the recruitment of the DNA translocase SftA to the Z-ring
Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation
Control of septum thickness by the curvature of SepF polymers
Do we really understand how antibiotics work?
A How-To Guide for Mode of Action Analysis of Antimicrobial Peptides
Multitarget Approaches against Multiresistant Superbugs
Membranaktive Antibiotika: neue Mechanismen gegen ein altbekanntes Ziel
The novel antibiotic rhodomyrtone traps membrane proteins in vesicles with increased fluidity
Effects of rhodomyrtone on Gram-positive bacterial tubulin homologue FtsZ
Antimicrobial peptide cWFW kills by combining lipid phase separation with autolysis
Editorial: Antimicrobial Peptides - Interaction with Membrane Lipids and Proteins
Free SepF interferes with recruitment of late cell division proteins
Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains
Purine biosynthesis is the bottleneck in trimethoprim-treated Bacillus subtilis
Influence of lipidation on the mode of action of a small RW-rich antimicrobial peptide
Antimicrobial Peptides from the Aurein Family Form Ion-Selective Pores in Bacillus subtilis
Small cationic antimicrobial peptides delocalize peripheral membrane proteins.
Inorganic and Organometallic Antimicrobial Peptides
Sandwich and Half-Sandwich Derivatives of Platensimycin: Synthesis and Biological Evaluation
Proteomic signatures in antibiotic research
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Showing 15 research projects
National excellence cluster in AI-driven antibiotic innovation
Antimicrobial materials: Saviors or drivers of the antimicrobial resistance problem?
New strategies for breaking intrinsic antibiotic resistance of mycobacteria
Revitalising the Antifungal Pipeline with Transition Metals
Shining light on the hidden moves: Nanoscale probing of bacterial activity
Detecting antibiotic-induced DNA damage in bacteria by single-molecule DNA microscopy
Can a membrane protein nanotrap inactivate multidrug efflux pumps?
Membrane microdomains in soil bacteria
Role of membrane microdomains in bacterial stress adaption and survival
Targeting bacterial stress responses - a new antibacterial strategy?
Antibiotic-induced amino acid release - A new antimicrobial strategy?
Nya strategier för att bryta inneboende antibiotikaresistens
Interaction of antibiotics with bacterial cells