Michaela Wenzel

Associate Professor at Chemical Biology

Michaela Wenzel is a microbiologist interested in antibiotic mechanisms of action and bacterial mechanisms of resistance. Her group uses fluorescence and electron microscopy together with proteomic and spectroscopic techniques to study the interaction of antimicrobial compounds with bacterial cells with a focus on the bacterial cell envelope. The goal is to provide a deeper fundamental understanding of how antibiotics interact with bacterial cells and use this knowledge to develop more sustainable antibiotics and novel antibacterial strategies.Michaela is vice director of the Center for Antibiotic Resistance Research in Gotheburg (CARe).

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Showing 16 publications

2024

Mimicking Nonribosomal Peptides from the Marine Actinomycete Streptomyces sp. H-KF8 Leads to Antimicrobial Peptides

Luisa I. Beyer, Ann-Britt Schäfer, Agustina Undabarrena et al
ACS Infectious Diseases. Vol. 10 (1), p. 79-92
Journal article
2023

Design, Synthesis, Molecular Modeling, Biological Activity, and Mechanism of Action of Novel Amino Acid Derivatives of Norfloxacin

Ahmed M. Kamal El-sagheir, Ireny Abdelmesseh Nekhala Abdelmesseh, Mohammed K. Abd El-Gaber et al
ACS Omega. Vol. 8 (45), p. 43271-43284
Journal article
2023

Rational design, synthesis, molecular modeling, biological activity, and mechanism of action of polypharmacological norfloxacin hydroxamic acid derivatives

Ahmed M. Kamal El-sagheir, Ireny Abdelmesseh Nekhala Abdelmesseh, Mohammed K. Abd El-Gaber et al
RSC MEDICINAL CHEMISTRY. Vol. In Press
Journal article
2023

Tracking Global and Local Changes in Membrane Fluidity Through Fluorescence Spectroscopy and Microscopy

Madeleine Humphrey, Ireny Abdelmesseh Nekhala Abdelmesseh, Kathi Scheinpflug et al
Methods in Molecular Biology, p. 203-229
Book chapter
2023

Dual Action of Eeyarestatin 24 on Sec-Dependent Protein Secretion and Bacterial DNA

Ann-Britt Schäfer, Maurice Steenhuis, Kin Ki Jim et al
ACS Infectious Diseases. Vol. 9 (2), p. 253-269
Journal article
2023

N4-Substituted Piperazinyl Norfloxacin Derivatives with Broad-Spectrum Activity and Multiple Mechanisms on Gyrase, Topoisomerase IV, and Bacterial Cell Wall Synthesis

Ahmed M. Kamal El-Sagheir, Ireny Abdelmesseh Nekhala Abdelmesseh, Mohammed K. Abd El-Gaber et al
ACS Bio and Med Chem Au. Vol. In Press
Journal article
2022

SepF supports the recruitment of the DNA translocase SftA to the Z-ring

Terrens N.V. Saaki, Zihao Teng, Michaela Wenzel et al
Molecular Microbiology. Vol. In Press
Journal article
2022

Roles of Bacterial Mechanosensitive Channels in Infection and Antibiotic Susceptibility

Margareth Sidarta, Luna Baruah, Michaela Wenzel
Pharmaceuticals. Vol. 15 (7)
Review article
2021

Control of septum thickness by the curvature of SepF polymers

Michaela Wenzel, Ilkay N. Celik Gulsoy, Yongqiang Gao et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 118 (2)
Journal article
2021

Comparison of proteomic responses as global approach to antibiotic mechanism of action elucidation

Christoph H.R. Senges, Jennifer J. Stepanek, Michaela Wenzel et al
Antimicrobial Agents and Chemotherapy. Vol. 65 (1)
Journal article
2021

A flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline

Michaela Wenzel, Marien P. Dekker, Biwen Wang et al
Communications Biology. Vol. 4 (1), p. 306-306
Journal article
2020

A How-To Guide for Mode of Action Analysis of Antimicrobial Peptides

Ann-Britt Schäfer, Michaela Wenzel
Frontiers in cellular and infection microbiology. Vol. 10
Review article
2020

Do we really understand how antibiotics work?

Michaela Wenzel
Future Microbiology. Vol. 15 (14), p. 1307-1311
Review article
2020

Multitarget Approaches against Multiresistant Superbugs

Declan Alan Gray, Michaela Wenzel
ACS Infectious Diseases. Vol. 6 (6), p. 1346-1365
Review article
2020

More than a pore: A current perspective on the in vivo mode of action of the lipopeptide antibiotic daptomycin

Declan Alan Gray, Michaela Wenzel
Antibiotics. Vol. 9 (1)
Review article
2019

Membranaktive Antibiotika: neue Mechanismen gegen ein altbekanntes Ziel

Michaela Wenzel
BioSpektrum. Vol. 25 (6), p. 683-683
Journal article

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Showing 9 research projects

2023–2025

New strategies for breaking intrinsic antibiotic resistance

Michaela Wenzel Chemical Biology
Stiftelsen Clas Groschinskys Minnesfond

2022–2022

Nya strategier för att bryta inneboende antibiotikaresistens

Michaela Wenzel Chemical Biology
Petrus och Augusta Hedlund stiftelse

2021–2023

New strategies to break intrinsic antibiotic resistance

Michaela Wenzel Chemical Biology
Stiftelsen Clas Groschinskys Minnesfond

2021–2024

Membrane microdomains in soil bacteria

Michaela Wenzel Chemical Biology
Formas

2021–2023

Role of membrane microdomains in bacterial stress adaption and survival

Michaela Wenzel Chemical Biology
Carl Tryggers Stiftelse för Vetenskaplig Forskning

2021–2022

Targeting bacterial stress responses - a new antibacterial strategy?

Michaela Wenzel Chemical Biology
Åke Wibergs Stiftelse

2020–2023

Antibiotic-induced amino acid release - A new antimicrobial strategy?

Michaela Wenzel Chemical Biology
Margareth Sidarta Chemical Biology
Swedish Research Council (VR)

1 publication exists
2019–2023

Interaction of antibiotics with bacterial cells

Michaela Wenzel Chemical Biology
Ann-Britt Schäfer Chemical Biology
Chalmers

2 publications exist
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