PRInted Symbiotic Materials as a dynamic platform for Living Tissues production
Research Project, 2022 – 2027

Living tissue manufacturing using symbiotic materials
The EU-funded PRISM-LT project will use a hybrid living materials concept to create a flexible platform for living tissue manufacturing. The innovative bio-ink will contain stem cells integrated into a supporting matrix with engineered helper bacteria or yeast cells. The bioprinting process will produce a 3D patterned structure where stem cells could be induced to differentiate into different lineages. The directed stimulation of differentiating stem cells will force them to produce lineage-specific metabolites for sensing by the designer helper cells. The helper cells within the platform will then enhance localised lineage commitment to sustain differentiation stability. The project aims to implement this strategy for the development of two symbiotic materials designed for biomedical and food applications, respectively.


Verena Siewers (contact)

Chalmers, Life Sciences, Systems and Synthetic Biology



Göteborg, Sweden


Udine, Italy

Radboud University

Nijmegen, Netherlands

University of Glasgow

Glasgow, United Kingdom


European Commission (EC)

Project ID: 101070913PRISM-LT
Funding Chalmers participation during 2022–2027

Related Areas of Advance and Infrastructure

Health Engineering

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