Verena Siewers

Forskare at Department of Biology and Biological Engineering, Systems and Synthetic Biology

Verena Siewers is a project leader at the Department of Biology and Biological Engineering in the Systems and Synthetic Biology Group. Her main research interest is the application of yeast as a cell factory for sustainable production of a variety of chemicals as well as advanced biofuels. This also includes the development of synthetic biology tools to improve the construction of efficient yeast strains. Verena Siewers is furthermore involved in the Novo Nordisk Foundation Center for Biosustainability and the FORMAS Center for Metabolic Engineering.

Source: chalmers.se

Projects

2016–2020

Model-Based Construction And Optimisation Of Versatile Chassis Yeast Strains For Production Of Valuable Lipid And Aromatic Compounds (CHASSY)

Jens B Nielsen Department of Biology and Biological Engineering, Systems and Synthetic Biology
Verena Siewers Department of Biology and Biological Engineering, Systems and Synthetic Biology
EC, Horizon 2020

2015–2020

Biological Production Systems 2014

Jens B Nielsen Department of Biology and Biological Engineering, Systems and Synthetic Biology
Verena Siewers Department of Biology and Biological Engineering, Systems and Synthetic Biology
Swedish Foundation for Strategic Research (SSF)

2014–2014

Avancerad produktion av kemikalier med jästcellsfabriker

Verena Siewers Kemi- och bioteknik, Livsvetenskaper
Konung Carl XVI Gustafs 50-årsfond

2013–2017

Yeast Cell Factories: Training Researchers to Apply Modern Post-Genomic Methods In Yeast Biotechnology (YEASTCELL)

Verena Siewers Department of Chemical and Biological Engineering, Systems Biology
Jens B Nielsen Department of Chemical and Biological Engineering, Systems Biology
Leonie Wenning Department of Chemical and Biological Engineering, Systems Biology
EC, Seventh Framework program (FP7)

2014–2015

Intracellular metabolic sensors for metabolic engineering of yeast

Verena Siewers Department of Chemical and Biological Engineering, Systems Biology
Carl Tryggers Stiftelse för Vetenskaplig Forskning

There might be more projects where Verena Siewers participates, but you have to be logged in as a Chalmers employee to see them.

Publications

2016

Affibody Scaffolds Improve Sesquiterpene Production in Saccharomyces cerevisiae.

Stefan Tippmann, Josefine Anfelt, Florian David et al
ACS synthetic biology
Scientific journal article - peer reviewed
2016

Evolutionary engineering reveals divergent paths when yeast is adapted to different acidic environments.

Eugene Fletcher, Amir Feizi, Markus M M Bisschops et al
Metabolic engineering
Scientific journal article - peer reviewed
2016

Establishing very long-chain fatty alcohol and wax ester biosynthesis in Saccharomyces cerevisiae.

Leonie Wenning, Tao Yu, Florian David et al
Biotechnology and bioengineering
Scientific journal article - peer reviewed
2016

Functional expression and evaluation of heterologous phosphoketolases in Saccharomyces cerevisiae

Alexandra Bergman, Verena Siewers, Jens B. Nielsen et al
AMB Express. Vol. 6
Scientific journal article - peer reviewed
2016

Harnessing yeast peroxisomes for biosynthesis of fatty-acid-derived biofuels and chemicals with relieved side-pathway competition

Yongjin Zhou, Nicolaas Buijs, Zhiwei Zhu et al
Journal of the American Chemical Society. Vol. 138 (47), p. 15368–15377
Scientific journal article - peer reviewed
2016

Production of fatty acid-derived oleochemicals and biofuels by synthetic yeast cell factories

Yongjin Zhou, Nicolaas Buijs, Zhiwei Zhu et al
Nature Communications. Vol. 7, p. 11709
Scientific journal article - peer reviewed
2016

Flux Control at the Malonyl-CoA Node through Hierarchical Dynamic Pathway Regulation in Saccharomyces cerevisiae

Florian David, Jens B. Nielsen, Verena Siewers et al
ACS Synthetic Biology. Vol. 5 (3), p. 224-233
Scientific journal article - peer reviewed
2016

Physiological and transcriptional characterization of Saccharomyces cerevisiae engineered for production of fatty acid ethyl esters

Bouke Wim de Jong, Verena Siewers, Jens B. Nielsen et al
FEMS Yeast Research. Vol. 16 (1)
Scientific journal article - peer reviewed
2016

Improved production of fatty acids by Saccharomyces cerevisiae through screening a cDNA library from the oleaginous yeast Yarrowia lipolytica

S. B. Shi, H. C. Ji, Verena Siewers et al
FEMS Yeast Research. Vol. 16 (1)
Scientific journal article - peer reviewed
2016

Production of farnesene and santalene by Saccharomyces cerevisiae using fed-batch cultivations with RQ-controlled feed

Stefan Tippmann, Gionata Scalcinati, Verena Siewers et al
Biotechnology and Bioengineering. Vol. 113 (1), p. 72-81
Scientific journal article - peer reviewed
2015

RNA-seq analysis of Pichia anomala reveals important mechanisms required for survival at low pH

Eugene Fletcher, Amir Feizi, S.S. Kim et al
Microbial Cell Factories. Vol. 14 (1)
Scientific journal article - peer reviewed
2015

Modular pathway rewiring of Saccharomyces cerevisiae enables high-level production of L-ornithine

J. Qin, Yongjin Zhou, Anastasia Krivoruchko et al
Nature Communications. Vol. 6 (Sept.), p. Art. no. 8224
Scientific journal article - peer reviewed
2015

Adaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain

Yiming Zhang, Guodong Liu, Martin Engqvist et al
Microbial Cell Factories. Vol. 14 (116)
Scientific journal article - peer reviewed
2015

Functional pyruvate formate lyase pathway expressed with two different electron donors in Saccharomyces cerevisiae at aerobic growth

Yiming Zhang, Zongjie Dai, Anastasia Krivoruchko et al
Fems Yeast Research. Vol. 15 (4)
Scientific journal article - peer reviewed
2015

Editorial: Yeast synthetic biology: new tools to unlock cellular function

H. S. Alper, H. A. Kang, Verena Siewers et al
Fems Yeast Research. Vol. 15 (1)
Scientific journal article - non peer reviewed
2015

Advances in yeast genome engineering

Florian David, Verena Siewers,
Fems Yeast Research. Vol. 15 (1)
Scientific journal article - peer reviewed
2015

Molecular Mechanism of Flocculation Self-Recognition in Yeast and Its Role in Mating and Survival

K. V. Y. Goossens, F. S. Ielasi, Intawat Nookaew et al
mBio. Vol. 6 (2)
Scientific journal article - peer reviewed
2015

Production of beta-ionone by combined expression of carotenogenic and plant CCD1 genes in Saccharomyces cerevisiae

J. Lopez, K. Essus, Il-Kwon Kim et al
Microbial Cell Factories. Vol. 14, p. Art. no. 84
Scientific journal article - peer reviewed
2015

Enabling Technologies to Advance Microbial Isoprenoid Production

Yun Chen, Yongjin Zhou, Verena Siewers et al
Advances in Biochemical Engineering/Biotechnology. Vol. 148, p. 143-160
Scientific journal article - peer reviewed
2015

Ach1 is involved in shuttling mitochondrial acetyl units for cytosolic C2 provision in Saccharomyces cerevisiae lacking pyruvate decarboxylase

Yun Chen, Yiming Zhang, Verena Siewers et al
FEMS Yeast Research. Vol. 15 (3)
Scientific journal article - peer reviewed
2015

Long-chain Alkane Production by the Yeast Saccharomyces cerevisiae

Nicolaas Buijs, Yongjin Zhou, Verena Siewers et al
Biotechnology and Bioengineering. Vol. 112 (6), p. 1275-1279
Scientific journal article - peer reviewed
2015

Microbial acetyl-CoA metabolism and metabolic engineering

Anastasia Krivoruchko, Yiming Zhang, Verena Siewers et al
Metabolic Engineering. Vol. 28, p. 28-42
Scientific journal article - peer reviewed
2015

Metabolic pathway engineering for fatty acid ethyl ester production in Saccharomyces cerevisiae using stable chromosomal integration

Bouke Wim de Jong, S. B. Shi, Juan Octavio Valle Rodriguez et al
Journal of Industrial Microbiology & Biotechnology. Vol. 42 (3), p. 477-486
Scientific journal article - peer reviewed
2014

Enhanced ethanol production and reduced glycerol formation in fps1∆ mutants of Saccharomyces cerevisiae engineered for improved redox balancing

Clara Navarrete, Jens B. Nielsen, Verena Siewers et al
AMB Express. Vol. 4
Scientific journal article - peer reviewed
2014

Engineering of Chromosomal Wax Ester Synthase Integrated Saccharomyces Cerevisiae Mutants for Improved Biosynthesis of Fatty Acid Ethyl Esters

Shuobo Shi, Juan Octavio Valle Rodriguez, Verena Siewers et al
Biotechnology and Bioengineering. Vol. 111 (9), p. 1740-1747
Scientific journal article - peer reviewed
2014

Improving Production of Malonyl Coenzyme A-Derived Metabolites by Abolishing Snf1-Dependent Regulation of Acc1

S. B. Shi, Yun Chen, Verena Siewers et al
Mbio. Vol. 5 (3)
Scientific journal article - peer reviewed
2014

Improved production of fatty acid ethyl esters in Saccharomyces cerevisiae through up-regulation of the ethanol degradation pathway and expression of the heterologous phosphoketolase pathway

Bouke Wim de Jong, S. Shi, Verena Siewers et al
Microbial Cell Factories. Vol. 13
Scientific journal article - peer reviewed
2014

Coupled incremental precursor and co-factor supply improves 3-hydroxypropionic acid production in Saccharomyces cerevisiae

Yun Chen, Jichen Bao, Il-Kwon Kim et al
Metabolic Engineering. Vol. 22, p. 104-109
Scientific journal article - peer reviewed
2014

Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid ethyl esters, an advanced biofuel, by eliminating non-essential fatty acid utilization pathways

Juan Octavio Valle Rodriguez, Shuobo Shi, Verena Siewers et al
Applied Energy. Vol. 115, p. 226-232
Scientific journal article - peer reviewed
2013

From flavors and pharmaceuticals to advanced biofuels: Production of isoprenoids in Saccharomyces cerevisiae

Stefan Tippmann, Yun Chen, Verena Siewers et al
Biotechnology Journal. Vol. 8 (12), p. 1435-1444
Scientific journal article - peer reviewed
2013

Improving biobutanol production in engineered Saccharomyces cerevisiae by manipulation of acetyl-CoA metabolism

Anastasia Krivoruchko, Cristina Serrano-Amatriain, Yun Chen et al
Journal of Industrial Microbiology & Biotechnology. Vol. 40 (9), p. 1051-1056
Scientific journal article - peer reviewed
2013

Advanced biofuel production by the yeast Saccharomyces cerevisiae

Nicolaas Buijs, Verena Siewers, Jens B. Nielsen et al
Current Opinion in Chemical Biology. Vol. 17 (3), p. 480-488
Scientific journal article - peer reviewed
2013

Improved polyhydroxybutyrate production by Saccharomyces cerevisiae through the use of the phosphoketolase pathway

Kanokarn Kocharin, Verena Siewers, Jens B. Nielsen et al
Biotechnology and Bioengineering. Vol. 110 (8), p. 2216-2224
Scientific journal article - peer reviewed
2013

A universal fixation method based on quaternary ammonium salts (RNAlater) for omics-technologies: Saccharomyces cerevisiae as a case study

R. G. E. van Eijsden, C. Stassen, L. Daenen et al
Biotechnology Letters. Vol. 35 (6), p. 891-900
Scientific journal article - peer reviewed
2013

Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism

Yun Chen, L. Daviet, M. Schalk et al
Metabolic Engineering. Vol. 15, p. 48-54
Scientific journal article - peer reviewed
2012

Reconstruction and Evaluation of the Synthetic Bacterial MEP Pathway in Saccharomyces cerevisiae

Siavash Partow, Verena Siewers, L. Daviet et al
PLoS ONE. Vol. 7 (12), p. Article Number: e52498
Scientific journal article - peer reviewed
2012

Combined metabolic engineering of precursor and co-factor supply to increase α-santalene production by Saccharomyces cerevisiae

Gionata Scalcinati, Siavash Partow, Verena Siewers et al
Microbial Cell Factories. Vol. 11, p. Article Number: 117
Scientific journal article - peer reviewed
2012

Engineering of acetyl-CoA metabolism for the improved production of polyhydroxybutyrate in Saccharomyces cerevisiae

Kanokarn Kocharin, Yun Chen, Verena Siewers et al
AMB Express. Vol. 2
Scientific journal article - peer reviewed
2012

Systems biology of yeast: enabling technology for development of cell factories for production of advanced biofuels

Bouke Wim de Jong, Verena Siewers, Jens B. Nielsen et al
Current Opinion in Biotechnology. Vol. 23 (4), p. 624-630
Scientific journal article - peer reviewed
2012

Profiling of Cytosolic and Peroxisomal Acetyl-CoA Metabolism in Saccharomyces cerevisiae

Yun Chen, Verena Siewers, Jens B. Nielsen et al
PLoS ONE. Vol. 7 (8), p. e42475
Scientific journal article - peer reviewed
2012

Enhancing the copy number of episomal plasmids in Saccharomyces cerevisiae for improved protein production

Yun Chen, Siavash Partow, Gionata Scalcinati et al
FEMS Yeast Research. Vol. 12 (5), p. 598-607
Scientific journal article - peer reviewed
2012

dynamic control of gene expression in saccharomyces cerevisiae engineered for the production of plant sesquiterpene alpha-santalene in a fed-batch mode

Gionata Scalcinati, Christoph Knuf, Siavash Partow et al
Metabolic Engineering. Vol. 14 (2), p. 91-103
Scientific journal article - peer reviewed
2012

Physiological characterization of recombinant Saccharomyces cerevisiae expressing the Aspergillus nidulans phosphoketolase pathway: validation of activity through (13)C-based metabolic flux analysis.

Marta Papini, Intawat Nookaew, Verena Siewers et al
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY . Vol. 95 (4), p. 1001-1010
Scientific journal article - peer reviewed
2012

A systems-level approach for metabolic engineering of yeast cell factories

Il-Kwon Kim, António Roldão, Verena Siewers et al
Fems Yeast Research. Vol. 12 (2), p. 228-248
Scientific journal article - peer reviewed
2012

Functional expression and characterization of five wax ester synthases in Saccharomyces cerevisiae and their utility for biodiesel production

Shuobo Shi, Juan Octavio Valle Rodriguez, Sakda Khoomrung et al
Biotechnology for Biofuels. Vol. 5, p. Art. no. 7
Scientific journal article - peer reviewed
2011

Prospects for microbial biodiesel production

Shuobo Shi, J. O. Valle-Rodriguez, Verena Siewers et al
Biotechnology Journal. Vol. 6 (3), p. 277-285
Scientific journal article - peer reviewed
2011

Opportunities for yeast metabolic engineering: Lessons from synthetic biology

Verena Siewers, Jens B. Nielsen, Anastasia Krivoruchko et al
Biotechnology Journal. Vol. 6 (3), p. 262-276
Scientific journal article - peer reviewed
2011

The Influence of Microgravity on Invasive Growth in Saccharomyces cerevisiae

S. E. Van Mulders, C. Stassen, L. Daenen et al
Astrobiology. Vol. 11 (1), p. 45-55
Scientific journal article - peer reviewed
2010

Characterization of different promoters for designing a new expression vector in Saccharomyces cerevisiae

Siavash Partow, Verena Siewers, S. Bjorn et al
Yeast. Vol. 27 (11), p. 955-964
Scientific journal article - peer reviewed
2010

Phosphoglycerate mutase knock-out mutant Saccharomyces cerevisiae: Physiological investigation and transcriptome analysis

Marta Papini, Intawat Nookaew, Gionata Scalcinati et al
Biotechnology Journal. Vol. 5 (10), p. 1016-1027
Scientific journal article - peer reviewed
2010

Implementation of communication-mediating domains for non-ribosomal peptide production in Saccharomyces cerevisae

Verena Siewers, Rita San-Bento, Jens B. Nielsen et al
Biotechnology and Bioengineering. Vol. 106 (5), p. 841-844
Scientific journal article - peer reviewed