Genetic biosensors for developing better cell factories for production of platform chemicals
Research Project, 2018 – 2020

Efficient biochemical conversion of renewable carbon sources is crucial for the transition into a resource efficient society. Industrial processes require strains that are tolerant to several stress conditions and display a high productivity, features to be developed in order for biobased chemicals and materials to be price-competitive.


The aim of this project is to develop genetic biosensors for yeast, that report intracellular concentrations of biochemicals produced by the cells or inhibitors found in the raw material. Inhibitors are abundant in lignocellulosic hydrolysates, a raw material made from plant biomass unsuited for use as food. The biosensors developed can be used for finding more robust and efficient cell factories with increased tolerance or for screening strains with an increased production of biochemicals.

Participants

Yvonne Nygård (contact)

Chalmers, Life Sciences, Industrial Biotechnology

Maurizio Mormino

Chalmers, Life Sciences, Industrial Biotechnology

Lisbeth Olsson

Chalmers, Life Sciences, Industrial Biotechnology

Verena Siewers

Chalmers, Life Sciences, Systems and Synthetic Biology

Collaborations

Indian Institute of Technology

Hyderabad, India

Technical Research Centre of Finland (VTT)

Espoo, Finland

Funding

ÅForsk

Funding Chalmers participation during 2018–2021

Adlerbertska Foundations

Funding Chalmers participation during 2018–2021

Formas

Project ID: 2017-00979
Funding Chalmers participation during 2018–2020

Ollie och Elof Ericssons stiftelser

Funding Chalmers participation during 2018–2022

Related Areas of Advance and Infrastructure

Sustainable development

Driving Forces

Energy

Areas of Advance

Life Science Engineering (2010-2018)

Areas of Advance

Publications

More information

Latest update

2024-05-29