Systems biology of yeast: enabling technology for development of cell factories for production of advanced biofuels
Journal article, 2012

Transportation fuels will gradually shift from oil based fuels towards alternative fuel resources like biofuels. Current bioethanol and biodiesel can, however, not cover the increasing demand for biofuels and there is therefore a need for advanced biofuels with superior fuel properties. Novel cell factories will provide a production platform for advanced biofuels. However, deep cellular understanding is required for improvement of current biofuel cell factories. Fast screening and analysis (-omics) methods and metabolome-wide mathematical models are promising techniques. An integrated systems approach of these techniques drives diversity and quantity of several new biofuel compounds. This review will cover the recent technological developments that support improvement of the advanced biofuels 1-butanol, biodiesels and jetfuels.

saccharomyces-cerevisiae

butanol production

mass-spectrometry

high-throughput

analysis

expression

metabolism

quantitative metabolomics

flux

escherichia-coli

acetobutylicum

Author

Bouke Wim de Jong

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Verena Siewers

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Jens B Nielsen

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Current Opinion in Biotechnology

0958-1669 (ISSN)

Vol. 23 4 624-630

Subject Categories

Biological Sciences

Areas of Advance

Life Science Engineering (2010-2018)

DOI

10.1016/j.copbio.2011.11.021

More information

Created

10/7/2017