Jens B Nielsen
Jens Nielsen is Professor of Quantitative Systems Biology.
Jens Nielsen has an MSc degree in Chemical Engineering and a PhD degree (1989) in Biochemical Engineering from the Danish Technical University (DTU), and after that established his independent research group and was appointed full Professor there in 1998. He was Fulbright visiting professor at MIT in 1995-1996. At DTU he founded and directed Center for Microbial Biotechnology. In 2008 he was recruited as Professor and Director to Chalmers University of Technology, Sweden, where he is directing a research group of more than 50 people. At Chalmers he established the Area of Advance Life Science Engineering, a cross departmental strategic research initiative and was founding Head of the Department of Biology and Biological Engineering, which now encompass more than 200 people. Jens Nielsen is also a co-founder of the Novo Nordisk Foundation Center for Biosustainability that now have more than 300 people affiliated, for which he served as Chief Science Officer in the period 2013-2018. In 2019 Jens Nielsen was appointed as CEO of the BioInnovation Institute in Denmark, which is a new institute that will foster translational research and support new spin-out companies in life sciences. Jens Nielsen has supervised more than 100 PhD students and more than 75 post doctoral researchers. He has published so far more than 700 papers that have been cited more than 65,000 times (current H-factor 118), and co-authored more than 40 books. He was identified as a highly cited researcher in 2015-2018. He is inventor of more than 50 patents and he has founded several biotech companies. He has received numerous Danish and international awards including the Nature Mentor Award, the ENI Award, the Eric and Sheila Samson Prime Minister Prize, the Novozymes Prize, and the Gold Medal from the Royal Swedish Academy of Engineering Sciences. He is member of several academies, including the National Academy of Engineering and National Academy of Science in USA, the Royal Swedish Academy of Science, the Royal Danish Academy of Science and Letters, the Royal Swedish Academy of Engineering Sciences and the American Academy of Microbiology. He is a founding president of the International Metabolic Engineering Society.
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Showing 692 publications
Brain energy metabolism is optimized to minimize the cost of enzyme synthesis and transport
Increased CO
Single-cell omics analysis with genome-scale metabolic modeling
Transcriptomic meta-analysis to identify potential antifungal targets in Candida albicans
The transition from 2G to 3G-feedstocks enabled efficient production of fuels and chemicals
Fine-tuning of p-coumaric acid synthesis to increase (2S)-naringenin production in yeast
Engineering yeast mitochondrial metabolism for 3-hydroxypropionate production
Metabolic engineering of human gut microbiome: Recent developments and future perspectives
Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast
Harnessing synthetic biology for mushroom farming
Modeling the metabolic dynamics at the genome-scale by optimized yield analysis
Engineering yeast to produce plant-derived anti-obesity agent
The acute effect of different NAD+ precursors included in the combined metabolic activators
Engineering yeast for high-level production of diterpenoid sclareol
GotEnzymes: an extensive database of enzyme parameter predictions
Deep learning-based k(cat) prediction enables improved enzyme-constrained model reconstruction
Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults
Microbiome and metabolome features of the cardiometabolic disease spectrum
Multiscale models quantifying yeast physiology: towards a whole-cell model
Multiomics Analysis Reveals the Impact of Microbiota on Host Metabolism in Hepatic Steatosis
Noninvasive detection of any-stage cancer using free glycosaminoglycans
Microbiome-derived ethanol in nonalcoholic fatty liver disease
Genome-scale modeling of yeast metabolism: retrospectives and perspectives
Machine learning for data integration in human gut microbiome
Metabolic reconfiguration enables synthetic reductive metabolism in yeast
Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning
Controlling gene expression with deep generative design of regulatory DNA
Microbial production of chemicals driven by CRISPR-Cas systems
Integrative functional analysis uncovers metabolic differences between Candida species
A Pan-Draft Metabolic Model Reflects Evolutionary Diversity across 332 Yeast Species
A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity
Yeast synthetic biology advances biofuel production
Professor Stefan Hohmann (08.09.1956-02.07.2021)
Cellular limitation of enzymatic capacity explains glutamine addiction in cancers
Innovation trends in industrial biotechnology
Yeast has evolved to minimize protein resource cost for synthesizing amino acids
Bioactive metabolites: The double-edged sword in your food
Learning deep representations of enzyme thermal adaptation
Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19
Performance of Regression Models as a Function of Experiment Noise
Metabolic cooperation and spatiotemporal niche partitioning in a kefir microbial community
Machine learning-based investigation of the cancer protein secretory pathway
Metabolic network remodelling enhances yeast’s fitness on xylose using aerobic glycolysis
Systems biology based drug repositioning for development of cancer therapy
Production of β-carotene in Saccharomyces cerevisiae through altering yeast lipid metabolism
Proteome Constraints in Genome-Scale Models
Transcriptomic response of Saccharomyces cerevisiae to octanoic acid production
Engineering yeast metabolism for the discovery and production of polyamines and polyamine analogues
Adaptations in metabolism and protein translation give rise to the Crabtree effect in yeast
Synthetic biology advanced natural product discovery
Metabolic Engineering of Yeast
In vitro turnover numbers do not reflect in vivo activities of yeast enzymes
Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers
Metabolic Engineering: Concepts and Applications: Volume 13a and 13b
Mathematical modeling of proteome constraints within metabolism
Draft genome sequences of five fungal strains isolated from Kefir
Rational gRNA design based on transcription factor binding data
Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning
Genome-scale insights into the metabolic versatility of Limosilactobacillus reuteri
The Translational Status of Cancer Liquid Biopsies
Yeast optimizes metal utilization based on metabolic network and enzyme kinetics
Production of 10-methyl branched fatty acids in yeast
De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories
Yeast based biorefineries for oleochemical production
Expression of fungal biosynthetic gene clusters in S. cerevisiae for natural product discovery
A single chromosome strain of S. cerevisiae exhibits diminished ethanol metabolism and tolerance
Strategies and challenges with the microbial conversion of methanol to high-value chemicals
Bayesian genome scale modelling identifies thermal determinants of yeast metabolism
The yeastGemMap: A process diagram to assist yeast systems-metabolic studies
Proteome constraints reveal targets for improving microbial fitness in nutrient-rich environments
Combinatorial, additive and dose-dependent drug–microbiome associations
Fatty acid synthesis is required for breast cancer brain metastasis
INetModels 2.0: An interactive visualization and database of multi-omics data
Yeast metabolic innovations emerged via expanded metabolic network and gene positive selection
Addressing the heterogeneity in liver diseases using biological networks
Stress-induced expression is enriched for evolutionarily young genes in diverse budding yeasts
Statin therapy is associated with lower prevalence of gut microbiota dysbiosis
Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning
MEMOTE for standardized genome-scale metabolic model testing
DSAVE: Detection of misclassified cells in single-cell RNA-Seq data
Current Status of COVID-19 Therapies and Drug Repositioning Applications
Rewiring carbon flux in Escherichia coli using a bifunctional molecular switch
Evolution from adherent to suspension: systems biology of HEK293 cell line development
Editorial: yeast synthetic biology
Yeast systems biology in understanding principles of physiology underlying complex human diseases
Advances in Metabolic Engineering of Saccharomyces cerevisiae for Cocoa Butter Equivalent Production
Pathway engineering in yeast for synthesizing the complex polyketide bikaverin
Metabolic Engineering of Saccharomyces cerevisiae for Rosmarinic Acid Production
Bioprospecting Through Cloning of Whole Natural Product Biosynthetic Gene Clusters
Engineering yeast phospholipid metabolism for de novo oleoylethanolamide production
Nitrogen limitation reveals large reserves in metabolic and translational capacities of yeast
A systems biology approach for studying neurodegenerative diseases
Comprehensive understanding of Saccharomyces cerevisiae phenotypes with whole-cell model WM_S288C
The role of peroxisomes in xylose alcoholic fermentation in the engineered Saccharomyces cerevisiae
Current state of aromatics production using yeast: achievements and challenges
Improvement in the Current Therapies for Hepatocellular Carcinoma Using a Systems Medicine Approach
Classification of clear cell renal cell carcinoma based on PKM alternative splicing
Building blocks are synthesized on demand during the yeast cell cycle
Sources of variation in cell-type RNA-Seq profiles
Third-generation biorefineries as the means to produce fuels and chemicals from CO2
Pan-cancer analysis of the metabolic reaction network
Dysregulated autophagy in muscle precursor cells from humans with type 2 diabetes
A bioinformatic pipeline to analyze ChIP-exo datasets
Saccharomyces cerevisiae displays a stable transcription start site landscape in multiple conditions
Machine Learning Applied to Predicting Microorganism Growth Temperatures and Enzyme Catalytic Optima
Recent trends in metabolic engineering of microbial chemical factories
Reconstruction and analysis of a Kluyveromyces marxianus genome-scale metabolic model
The pan-genome of Saccharomyces cerevisiae
Tackling Cancer with Yeast-Based Technologies
Systems biology perspective for studying the gut microbiota in human physiology and liver diseases
Metagenomic analysis of bile salt biotransformation in the human gut microbiome
Assembly and analysis of the genome sequence of the yeast Brettanomyces naardenensis CBS 7540
Yeast Systems Biology: Model Organism and Cell Factory
METABOLISM: A stress-coping strategy for yeast cells
Adaptive laboratory evolution of tolerance to dicarboxylic acids in Saccharomyces cerevisiae
Proteome analysis of xylose metabolism in Rhodotorula toruloides during lipid production
Model-Assisted Fine-Tuning of Central Carbon Metabolism in Yeast through dCas9-Based Regulation
Cell factory engineering for improved production of natural products
Big data in yeast systems biology
Antibiotic Lethality Is Impacted by Nutrient Availabilities: New Insights from Machine Learning
Modelling approaches for studying the microbiome
Energy metabolism controls phenotypes by protein efficiency and allocation
Genome-scale model of Rhodotorula toruloides metabolism
Rewiring carbon metabolism in yeast for high level production of aromatic chemicals
Complex I is bypassed during high intensity exercise
Metagenomic analysis of microbe-mediated vitamin metabolism in the human gut microbiome
Expanding the Dynamic Range of a Transcription Factor-Based Biosensor in Saccharomyces cerevisiae
Global rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative
Balanced trafficking between the ER and the Golgi apparatus increases protein secretion in yeast
Metabolite secretion in microorganisms: the theory of metabolic overflow put to the test
Heterologous transporter expression for improved fatty alcohol secretion in yeast
Impact of forced fatty acid synthesis on metabolism and physiology of Saccharomyces cerevisiae
Regulation of yeast-to-hyphae transition in Yarrowia lipolytica
Guidelines and recommendations on yeast cell death nomenclature
Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors
Screening of 2A peptides for polycistronic gene expression in yeast
High-throughput microfluidics for the screening of yeast libraries
Reprogramming Yeast Metabolism from Alcoholic Fermentation to Lipogenesis
TCSBN: A database of tissue and cancer specific biological networks
Expression of cocoa genes in Saccharomyces cerevisiae improves cocoa butter production
Coupling cell division to metabolic pathways through transcription
Systems biology in hepatology: Approaches and applications
Barriers and opportunities in bio-based production of hydrocarbons
Metabolic engineering of Saccharomyces cerevisiae for overproduction of triacylglycerols
Metabolite Depletion Affects Flux Profiling of Cell Lines
Investigation of putative regulatory acetylation sites in Fas2p of Saccharomyces cerevisiae
Evolution of the Metabolic Engineering Community
Advancing biotechnology with CRISPR/Cas9: recent applications and patent landscape
Redirection of lipid flux toward phospholipids in yeast increases fatty acid turnover and secretion
In vitro co-cultures of human gut bacterial species as predicted from co-occurrence network analysis
Challenges in modeling the human gut microbiome
Dynamic engineering of 1-alkenes biosynthesis and secretion in yeast.
Drug Repositioning for Effective Prostate Cancer Treatment
Changes in lipid metabolism convey acid tolerance in Saccharomyces cerevisiae
Multiplexed CRISPR/Cas9 Genome Editing and Gene Regulation Using Csy4 in Saccharomyces cerevisiae
Efficient protein production by yeast requires global tuning of metabolism
METABOLISM: Built on stable catalysts
Comparison of the metabolic response to over-production of p-coumaric acid in two yeast strains
Editorial: Where is scientific publishing heading?
Affibody Scaffolds Improve Sesquiterpene Production in Saccharomyces cerevisiae.
Metabolic Models of Protein Allocation Call for the Kinetome
Moderate Expression of SEC16 Increases Protein Secretion by Saccharomyces cerevisiae
Genome-scale metabolic models applied to human health and disease
The yeast osmostress response is carbon source dependent
Predicting growth of the healthy infant using a genome scale metabolic model.
Anticancer drug discovery through genome-scale metabolic modeling
Improving the economics of NASH/NAFLD treatment through the use of systems biology
Exploring the potential of Saccharomyces cerevisiae for biopharmaceutical protein production
Biobased production of alkanes and alkenes through metabolic engineering of microorganisms
Systematic inference of functional phosphorylation events in yeast metabolism
Systems Biology of Metabolism: A Driver for Developing Personalized and Precision Medicine
Enabling the synthesis of medium chain alkanes and 1-alkenes in yeast
Metabolic engineering frontiers emerging with advanced tools and methodologies
The Impact of Systems Biology on Bioprocessing
Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes
A molecular genetic toolbox for Yarrowia lipolytica
Physiological characterization of secondary metabolite producing Penicillium cell factories
Engineering Robustness of Microbial Cell Factories
Engineering central metabolism – a grand challenge for plant biologists
Exploiting off-targeting in guide-RNAs for CRISPR systems for simultaneous editing of multiple genes
Network analyses identify liver-specific targets for treating liver diseases
Selection of complementary foods based on optimal nutritional values
Transcriptional reprogramming in yeast using dCas9 and combinatorial gRNA strategies
Leucine Biosynthesis Is Involved in Regulating High Lipid Accumulation in Yarrowia lipolytica
Expanding the product portfolio of fungal type I fatty acid synthases
New challenges to study heterogeneity in cancer redox metabolism
Establishing very long-chain fatty alcohol and wax ester biosynthesis in Saccharomyces cerevisiae
Genome scale metabolic modeling of cancer
Metabolic engineering of yeast for fermentative production of flavonoids
Regulation of amino-acid metabolism controls flux to lipid accumulation in yarrowia lipolytica
Engineering yeast metabolism for production of fuels and chemicals
Editorial: The Impact of Systems Medicine on Human Health and Disease
Prognostic Value of Plasma and Urine glycosaminoglycan scores in clear cell renal cell carcinoma
Engineering yeast for high-level production of stilbenoid antioxidants
Flux control through protein phosphorylation in yeast
Systematic analysis of overall survival and interactions between tumor mutations and drug treatment
Engineering Cellular Metabolism
Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis
Thermotolerant yeasts selected by adaptive evolution express heat stress response at 30 degrees C
Human gut microbiota and healthy aging: Recent developments and future prospective
Transcriptomics resources of human tissues and organs
Industrial systems biology and its impact on synthetic biology of yeast cell factories
Adaptive Evolution of Phosphorus Metabolism in Prochlorococcus.
Engineering of synthetic, stress-responsive yeast promoters
In search for symmetries in the metabolism of cancer
Functional expression and evaluation of heterologous phosphoketolases in Saccharomyces cerevisiae
Heme metabolism in stress regulation and protein production: From Cinderella to a key player.
sTrehalose-6-phosphate synthase and stabilization of yeast glycolysis
Adaptation to different types of stress converge on mitochondrial metabolism
Metabolic Trade-offs in Yeast are Caused by F1F0-ATP synthase
Integrative analysis of human omics data using biomolecular networks
Production of fatty acid-derived oleochemicals and biofuels by synthetic yeast cell factories
Biobased organic acids production by metabolically engineered microorganisms
Long-chain Alkane Production by the Yeast Saccharomyces cerevisiae
HCSD: The human cancer secretome database
Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling
Modifying yeast tolerance to inhibitory conditions of ethanol production processes
Microbial acetyl-CoA metabolism and metabolic engineering
Yeast cell factories on the horizon: Metabolic engineering in yeast gets increasingly more versatile
Genetic and nutrient modulation of acetyl-CoA levels in Synechocystis for n-butanol production
New insight into the gut microbiome through metagenomics
RNA-seq analysis of Pichia anomala reveals important mechanisms required for survival at low pH
How to set up collaborations between academia and industrial biotech companies
Tissue-based map of the human proteome
Metabolic engineering strategies for microbial synthesis of oleochemicals
New paradigms for metabolic modeling of human cells
Networking in metabolism and human disease
Micro-droplet based directed evolution outperforms conventional laboratory evolution
Enhanced amino acid utilization sustains growth of cells lacking Snf1/AMPK
Logical transformation of genome-scale metabolic models for gene level applications and analysis
Finding directionality and gene-disease predictions in disease associations
Applications of computational modeling in metabolic engineering of yeast
Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization
Genome scale models of yeast: towards standardized evaluation and consistent omic integration
Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome
Advancing metabolic engineering through systems biology of industrial microorganisms
Production of natural products through metabolic engineering of Saccharomyces cerevisiae
The gut microbiota modulates host amino acid and glutathione metabolism in mice
Glucose repression in Saccharomyces cerevisiae
Minimum Information about a Biosynthetic Gene cluster
Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism
Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals
Modular pathway rewiring of Saccharomyces cerevisiae enables high-level production of L-ornithine
De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae
FEMS yeast research: the yeast community journal
Do genome-scale models need exact solvers or clearer standards?
From next-generation sequencing to systematic modeling of the gut microbiome
Human metabolic atlas: an online resource for human metabolism
Cancer Metabolism: A Modeling Perspective
Enabling Technologies to Advance Microbial Isoprenoid Production
Molecular Mechanism of Flocculation Self-Recognition in Yeast and Its Role in Mating and Survival
ANT: Software for Generating and Evaluating Degenerate Codons for Natural and Expanded Genetic Codes
Unlocking the potential of fungi: the QuantFung project
Most influential FEMS publications
Genome Scale Metabolic Modeling of the Riboflavin Overproducer Ashbya gossypii
Defining the human gallbladder proteome by transcriptomics and affinity proteomics
A dedicated database system for handling multi-level data in systems biology
Bridging the gaps in systems biology
High-throughput screening for industrial enzyme production hosts by droplet microfluidics
Evolution reveals a glutathione-dependent mechanism of 3-hydroxypropionic acid tolerance
Altered sterol composition renders yeast thermotolerant
Maintaining a strong yeast research community
Kiwi: a tool for integration and visualization of network topology and gene-set analysis
Genome-Scale Metabolic Models: A Link between Bioinformatics and Systems Biology
Management of the endoplasmic reticulum stress by activation of the heat shock response in yeast
The human liver-specific proteome defined by transcriptomics and antibody-based profiling
Synthetic Biology for Engineering Acetyl Coenzyme A Metabolism in Yeast
Physiological characterization of the high malic acid-producing Aspergillus oryzae strain 2103a-68
BioMet Toolbox 2.0: genome-wide analysis of metabolism and omics data
Systems biology: Developments and applications
Impact of protein uptake and degradation on recombinant protein secretion in yeast
Kinetic models in industrial biotechnology - Improving cell factory performance
Development of a yeast cell factory for production of aromatic products
Defining the Human Adipose Tissue Proteome To Reveal Metabolic Alterations in Obesity
Genome-scale analysis of the high-efficient protein secretion system of Aspergillus oryzae
The use of Genome-scale metabolic models for drug target and biomarker identification
Engineering synergy in biotechnology
Advances in metabolic engineering of yeast Saccharomyces cerevisiae for production of chemicals
Mapping condition-dependent regulation of metabolism in yeast through genome-scale modeling
FANTOM: Functional and taxonomic analysis of metagenomes
Yeast as a platform cell factory in future biorefineries
Genome-Scale Modeling of the Protein Secretory Machinery in Yeast
Assessing the human gut microbiota in metabolic diseases.
Metabolic engineering of yeast for production of fuels and chemicals
Investigation of Malic Acid Production in Aspergillus oryzae under Nitrogen Starvation Conditions
Rapid Quantification of Yeast Lipid using Microwave-Assisted Total Lipid Extraction and HPLC-CAD
The role of biofuels in the future energy supply
Genome-scale modeling of human metabolism - a systems biology approach.
Understanding the interactions between bacteria in the human gut through metabolic modeling
Application of genome-scale metabolic models in metabolic engineering
Correlation of cell growth and heterologous protein production by Saccharomyces cerevisiae
Economic and environmental impacts of microbial biodiesel
Gut metagenome in European women with normal, impaired and diabetic glucose control
Novel insights into obesity and diabetes through genome-scale metabolic modeling
Mapping Condition-Dependent Regulation of Lipid Metabolism in Saccharomyces cerevisiae
A community-driven global reconstruction of human metabolism
Quantitative Analysis of Glycerol Accumulation, Glycolysis and Growth under Hyper Osmotic Stress
Production of biopharmaceutical proteins by yeast Advances through metabolic engineering
Droplet based directed evolution of yeast cell factories doubles production of industrial enzymes
Advanced biofuel production by the yeast Saccharomyces cerevisiae
Using Transcriptomics To Improve Butanol Tolerance of Synechocystis sp Strain PCC 6803
Integration of clinical data with a genome-scale metabolic model of the human adipocyte
Heat shock response improves heterologous protein secretion in Saccharomyces cerevisiae
Adaptively evolved yeast mutants on galactose show trade-offs in carbon utilization on glucose
Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism
Industrial Systems Biology of Saccharomyces cerevisiae Enables Novel Succinic Acid Cell Factory
Different expression systems for production of recombinant proteins in Saccharomyces cerevisiae
Reconstruction and Evaluation of the Synthetic Bacterial MEP Pathway in Saccharomyces cerevisiae
Symptomatic atherosclerosis is associated with an altered gut metagenome
Profiling of Cytosolic and Peroxisomal Acetyl-CoA Metabolism in Saccharomyces cerevisiae
Lipid biosynthesis monitored at the single-cell level in Saccharomyces cerevisiae
Applied systems biology - vanillin production in Saccharomyces cerevisiae
Fifteen years of large scale metabolic modeling of yeast: Developments and impacts
Genome-scale metabolic representation of Amycolatopsis balhimycina
Industrial glucoamylase fed-batch benefits from oxygen limitation and high osmolarity
Aspergilli: Systems biology and industrial applications
Systems biology: the 'new biotechnology' Editorial overview
Mapping the polysaccharide degradation potential of Aspergillus niger
Translational and systems medicine Introduction
Systems medicine and metabolic modelling
Evolutionary engineering of Saccharomyces cerevisiae for efficient aerobic xylose consumption
A systems-level approach for metabolic engineering of yeast cell factories
Metabolic engineering, synthetic biology and systems biology
Recovery of phenotypes obtained by adaptive evolution through inverse metabolic engineering
Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae
Bridging omics technologies with synthetic biology in yeast industrial biotechnology
The Influence of Microgravity on Invasive Growth in Saccharomyces cerevisiae
Codon usage variability determines the correlation between proteome and transcriptome fold changes
Genome-scale metabolic models of Saccharomyces cerevisiae
Prospects for microbial biodiesel production
Synergies between synthetic biology and metabolic engineering
Fermentation kinetics: Central and modern concepts
MEMOSys: Bioinformatics platform for genome-scale metabolic models
BIOFUELS Chimeric synthetic pathways
Molecular and process design for rotavirus-like particle production in Saccharomyces cerevisiae
Opportunities for yeast metabolic engineering: Lessons from synthetic biology
Transcriptional control of metabolic fluxes
Mapping the interaction of Snf1 with TORC1 in Saccharomyces cerevisiae
Molecular Basis for Mycophenolic Acid Biosynthesis in Penicillium brevicompactum
Prospects for systems biology and modeling of the gut microbiome
Mathematical models of cell factories: moving towards the core of industrial biotechnology
BioMet Toolbox: genome-wide analysis of metabolism
Systems Biology of lipid metabolism: From yeast to human
OptFlux: an open-source software platform for in silico metabolic engineering
Identification of flux control in metabolic networks using non-equilibrium thermodynamics
Systems biology of microorganisms
Use of genome-scale metabolic models for understanding microbial physiology
Analysis of Genome-Wide Coexpression and Coevolution of Aspergillus oryzae and Aspergillus niger
Transcriptional progression of atrophic gastritis development in humans
Toward Design-based Engineering of Industrial Microbes
Measuring enzyme activities under standardized in-vivo like conditions for systems biology
Systems Biology of Industrial Microorganisms
Systems biology of energy homeostasis in yeast
Global transcriptional response of Saccharomyces cerevisiae to the deletion of SDH3
Systemic analysis of the response of Aspergillus niger to ambient pH
Yeast as a Prototype for Systems Biology
In-depth analysis of Aspergillus niger metabolism during industrial fed-batch fermentations
Genome-wide analysis of maltose utilization and regulation in aspergilli
The 2008 update of the Aspergillus nidulans genome annotation: A community effort
Random sampling of metabolic networks
Systems biology of lipid metabolism: From yeast to human
Structure and flux analysis of metabolic networks
Overexpression of isocitrate lyase-glyoxylate bypass influence on matabolism in Aspergillus niger
Physiological characterisation of acuB deletion in Aspergillus niger
Developing appropriate hosts for metabolic engineering (Section V. - Introduction)
Current status of systems biology in Aspergilli
Nutritional Systems Biology: Definitions and Approaches
Qualification of flux control in metabolic pathways
Recombinant bacterial hemoglobin alters metabolism of Aspergillus niger
Heterologous production of non-ribosomal peptide LLD-ACV in Saccharomyces cerevisiae
Metabolic engineering of streptomyces
A trispecies Aspergillus microarray: Comparative transcriptomics of three Aspergillus species
Analysis of Aspergillus nidulans metabolism at the genome-scale
Reconstruction of a bacterial isoprenoid biosynthetic pathway in Saccharomyces cerevisiae
Natural computation meta-heuristics for the in silico optimization of microbial strains
Systems biology: Is the hope worth the hype
Can yeast systems biology contribute to the understanding of human disease?
Production of the polyketide 6-MSA in yeast engineered for increased malonyl-CoA supply
Penicillium chrysogenum is involved in regulation of b-lactam production
Physiological characterization of glucose repression in the strains with SNF1 and SNF4 genes deleted
Improved annotation through genome-scale metabolic modeling of Aspergillus oryzae
Metabolomics. Topics in Current Genetics
Metabolic model integration of the bibliome, genome, metabolome and reactome of Aspergillus Niger
Antibiotic overproduction in Streptomyces coelicolor A3(2) mediated by phosphofructokinase deletion
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Showing 33 research projects
Production of Benzylisoquinoline Alkaloids in Yeast
Yeast cell factories for advanced biofuels and microbial robustness
Engineering a robust biocatalyst for sustainable biofuel production
Mätning av glykosaminoglykaner till cancerdiagnostik
Systembiologi av eukaryal proteinsekretion
Biobaserad produktion av diesel och jetbränsle
Syntetisk biologi för biosyntes och produktion av naturliga produkter
Predictive and Accelerated Metabolic Engineering Network (PAcMEN)
Gut microbiome effects on cardiometabolic disease through metabolism-modifying metabolites (Gut-MMM)
Bioinformatics Services for Data-Driven Design of Cell Factories and Communities (DD-DeCaF)
Mapping the Transcription Factor Network of Yeast
Transkriptionsreglering i jäst på genomnivå
Mathematical modelling of tissue metabolism in response to malnutrition, II
Biological Production Systems 2014
Mathematical modeling of tissue metabolism in response to malnutrition
Quantitative Biology for Fungal Secondary Metabolite Producers (QUANTFUNG)
Biobased production of diesel and jetfuel
Engineering the Secretory Pathway for Recombinant Protein Secretion in Saccharomyces cerevisiae
Metagenomics in Cardiometabolic Diseases (METACARDIS)
Optimizing oil production in oleaginous yeast by cell-wide measurements and genome-based models
Infrastructure for Systems Biology - Europe (ISBE)
Biomarkers For Enhanced Vaccine Safety (BioVacSafe)
Industrial Systems Biology of Yeast and A. oryzae (INSYSBIO)