A systems biology approach for studying neurodegenerative diseases
Review article, 2020

Neurodegenerative diseases (NDDs), such as Alzheimer's (AD) and Parkinson's (PD), are among the leading causes of lost years of healthy life and exert a great strain on public healthcare systems. Despite being first described more than a century ago, no effective cure exists for AD or PD. Although extensively characterised at the molecular level, traditional neurodegeneration research remains marred by narrow-sense approaches surrounding amyloid β (Aβ), tau, and α-synuclein (α-syn). A systems biology approach enables the integration of multi-omics data and informs discovery of biomarkers, drug targets, and treatment strategies. Here, we present a comprehensive timeline of high-throughput data collection, and associated biotechnological advancements and computational analysis related to AD and PD. We hereby propose that a philosophical change in the definitions of AD and PD is now needed.


Simon Lam

King's College London

Abdulahad Bayraktar

King's College London

C. Zhang

Royal Institute of Technology (KTH)

Hasan Turkez

Atatürk University

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jan Borén

Wallenberg Lab.

Saeed Shoaie

King's College London

Royal Institute of Technology (KTH)

Mathias Uhlen

Royal Institute of Technology (KTH)

Adil Mardinoglu

King's College London

Royal Institute of Technology (KTH)

Drug Discovery Today

1359-6446 (ISSN)

Vol. 25 7 1146-1159

Subject Categories

Biomedical Laboratory Science/Technology

Bioinformatics (Computational Biology)

Computer Science





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