A systems biology approach for studying neurodegenerative diseases
Review article, 2020
Neurodegenerative diseases (NDDs), such as Alzheimer's (AD) and Parkinson's (PD), are among the leading causes of lost years of healthy life and exert a great strain on public healthcare systems. Despite being first described more than a century ago, no effective cure exists for AD or PD. Although extensively characterised at the molecular level, traditional neurodegeneration research remains marred by narrow-sense approaches surrounding amyloid β (Aβ), tau, and α-synuclein (α-syn). A systems biology approach enables the integration of multi-omics data and informs discovery of biomarkers, drug targets, and treatment strategies. Here, we present a comprehensive timeline of high-throughput data collection, and associated biotechnological advancements and computational analysis related to AD and PD. We hereby propose that a philosophical change in the definitions of AD and PD is now needed.
Author
Simon Lam
King's College London
Abdulahad Bayraktar
King's College London
C. Zhang
Royal Institute of Technology (KTH)
Hasan Turkez
Atatürk University
Jens B Nielsen
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Jan Borén
Wallenberg Lab.
Saeed Shoaie
King's College London
Royal Institute of Technology (KTH)
Mathias Uhlen
Royal Institute of Technology (KTH)
Adil Mardinoglu
King's College London
Royal Institute of Technology (KTH)
Drug Discovery Today
1359-6446 (ISSN) 18785832 (eISSN)
Vol. 25 7 1146-1159Subject Categories
Biomedical Laboratory Science/Technology
Bioinformatics (Computational Biology)
Computer Science
DOI
10.1016/j.drudis.2020.05.010
PubMed
32442631