A systems biology approach for studying neurodegenerative diseases
Reviewartikel, 2020
Neurodegenerative diseases (NDDs), such as Alzheimer's (AD) and Parkinson's (PD), are among the leading causes of lost years of healthy life and exert a great strain on public healthcare systems. Despite being first described more than a century ago, no effective cure exists for AD or PD. Although extensively characterised at the molecular level, traditional neurodegeneration research remains marred by narrow-sense approaches surrounding amyloid β (Aβ), tau, and α-synuclein (α-syn). A systems biology approach enables the integration of multi-omics data and informs discovery of biomarkers, drug targets, and treatment strategies. Here, we present a comprehensive timeline of high-throughput data collection, and associated biotechnological advancements and computational analysis related to AD and PD. We hereby propose that a philosophical change in the definitions of AD and PD is now needed.
Författare
Simon Lam
King's College London
Abdulahad Bayraktar
King's College London
C. Zhang
Kungliga Tekniska Högskolan (KTH)
Hasan Turkez
Atatürk Üniversitesi
Jens B Nielsen
Chalmers, Biologi och bioteknik, Systembiologi
Jan Borén
Wallenberg Lab.
Saeed Shoaie
King's College London
Kungliga Tekniska Högskolan (KTH)
Mathias Uhlen
Kungliga Tekniska Högskolan (KTH)
Adil Mardinoglu
King's College London
Kungliga Tekniska Högskolan (KTH)
Drug Discovery Today
1359-6446 (ISSN) 18785832 (eISSN)
Vol. 25 7 1146-1159Ämneskategorier
Biomedicinsk laboratorievetenskap/teknologi
Bioinformatik (beräkningsbiologi)
Datavetenskap (datalogi)
DOI
10.1016/j.drudis.2020.05.010
PubMed
32442631