A systems biology approach for studying neurodegenerative diseases
Reviewartikel, 2020

Neurodegenerative diseases (NDDs), such as Alzheimer's (AD) and Parkinson's (PD), are among the leading causes of lost years of healthy life and exert a great strain on public healthcare systems. Despite being first described more than a century ago, no effective cure exists for AD or PD. Although extensively characterised at the molecular level, traditional neurodegeneration research remains marred by narrow-sense approaches surrounding amyloid β (Aβ), tau, and α-synuclein (α-syn). A systems biology approach enables the integration of multi-omics data and informs discovery of biomarkers, drug targets, and treatment strategies. Here, we present a comprehensive timeline of high-throughput data collection, and associated biotechnological advancements and computational analysis related to AD and PD. We hereby propose that a philosophical change in the definitions of AD and PD is now needed.

Författare

Simon Lam

King's College London

Abdulahad Bayraktar

King's College London

C. Zhang

Kungliga Tekniska Högskolan (KTH)

Hasan Turkez

Atatürk Üniversitesi

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Jan Borén

Wallenberg Lab.

Saeed Shoaie

Kungliga Tekniska Högskolan (KTH)

King's College London

Mathias Uhlen

Kungliga Tekniska Högskolan (KTH)

Adil Mardinoglu

Kungliga Tekniska Högskolan (KTH)

King's College London

Drug Discovery Today

1359-6446 (ISSN)

Vol. In Press

Ämneskategorier

Biomedicinsk laboratorievetenskap/teknologi

Bioinformatik (beräkningsbiologi)

Datavetenskap (datalogi)

DOI

10.1016/j.drudis.2020.05.010

PubMed

32442631

Mer information

Senast uppdaterat

2020-06-30