Adil Mardinoglu
Forskarassistent at
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Dr. Adil Mardinoglu works in Systems Biology group and his research is focused on the establishment of Human Metabolic Atlas (HMA), an interactive data analysis and model simulation platform. HMA platform employ systems biology approaches to elucidate some of the genes, metabolites and reactions that are underlying several complex diseases such as obesity and its adverse outcomes. Healthcare professionals and pharmaceutical developers may harvest and translate the outcomes of HMA platform into the benefit of patients, find new therapies and eventually determine more effective personalized medicine for variety of diseases.
Source: chalmers.se
Projects
2014–2018
Integrating Modelling of Metabolism and Signalling towards an Application in Liver Cancer (ERASysAPP - IMOMESIC)
Jens B Nielsen
Biology and Biological Engineering
Avlant Nilsson
Systems and Synthetic Biology
Adil Mardinoglu
Systems and Synthetic Biology
Swedish Research Council (VR)
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Publications
2017
AUP1 (Ancient Ubiquitous Protein 1): A Molecular Link Between Hepatic Lipid Mobilization and VLDL Secretion
Adil Mardinoglu, Jan Borén,
Arteriosclerosis Thrombosis and Vascular Biology. Vol. 37 (4), p. 609-610
Scientific journal article - non peer reviewed
2017
Personal model-assisted identification of NAD(+) and glutathione metabolism as intervention target in NAFLD
Adil Mardinoglu, Elias Björnson, C. Zhang et al
Molecular Systems Biology. Vol. 13 (3)
Scientific journal article - peer reviewed
2017
Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins
S. Heinonen, M. Muniandy, J. Buzkova et al
Diabetologia. Vol. 60 (1), p. 169-181
Scientific journal article - peer reviewed
2016
Integrated Network Modeling for Novel Target Searches and Better Predictive Models
Adil Mardinoglu, J. Bosley,
Journal of Pharmacokinetics and Pharmacodynamics. Vol. 43, p. S88-S88
Conference paper - non peer reviewed
2016
Adaptive Evolution of Phosphorus Metabolism in Prochlorococcus.
John R Casey, Adil Mardinoglu, Jens B. Nielsen et al
mSystems. Vol. 1 (6)
Scientific journal article - peer reviewed
2016
Editorial: The Impact of Systems Medicine on Human Health and Disease
Adil Mardinoglu, Jens B. Nielsen,
Frontiers in Physiology. Vol. 7
Scientific journal article - non peer reviewed
2016
Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis
S. Lee, Adil Mardinoglu, C. Zhang et al
Nucleic Acids Research. Vol. 44 (12), p. 5529-5539
Scientific journal article - peer reviewed
2016
Phenotypic and genetic variance: a systems approach to the liver
Adil Mardinoglu, M. Uhlen,
Nature Reviews Gastroenterology & Hepatology. Vol. 13 (8), p. 439-440
Scientific journal article - non peer reviewed
2016
Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance
S. Lee, C. Zhang, M. Kilicarslan et al
Cell Metabolism. Vol. 24 (1), p. 172-184
Scientific journal article - peer reviewed
2016
ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism
Aditi Chaudhari, Liliana Håversen, Reza Mobini et al
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. Vol. 1861 (11), p. 1643-1651
Scientific journal article - peer reviewed
2016
Transcriptomics resources of human tissues and organs
M. Uhlen, B. M. Hallstrom, C. Lindskog et al
Molecular Systems Biology. Vol. 12 (4)
Scientific journal article - peer reviewed
2016
Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism
Ibrahim El-Semman, Adil Mardinoglu, Saeed Shoaie et al
Molecular Biosystems. Vol. 12 (5), p. 1496-1506
Scientific journal article - peer reviewed
2016
Investigating the Combinatory Effects of Biological Networks on Gene Co-expression
C. Zhang, S. Lee, Adil Mardinoglu et al
Frontiers in Physiology. Vol. 7
Scientific journal article - peer reviewed
2016
Confounding effects of metformin on the human gut microbiome in Type 2 diabetes
Adil Mardinoglu, Jan Borén, Ulf Smith et al
Cell Metabolism. Vol. 23 (1), p. 10-12
Scientific journal article - peer reviewed
2016
Personalized Cardiovascular Disease Prediction and Treatment-A Review of Existing Strategies and Novel Systems Medicine Tools
Elias Björnson, J. Boren, Adil Mardinoglu et al
Frontiers in Physiology. Vol. 7
Scientific journal article - peer reviewed
2015
Cancer Metabolism: A Modeling Perspective
Pouyan Ghaffari Nouran, Adil Mardinoglu, Jens B. Nielsen et al
Frontiers in Physiology. Vol. 6
Scientific journal article - peer reviewed
2015
Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization
Elias Björnson, B. Mukhopadhyay, A. Asplund et al
Cell Reports. Vol. 13 (9), p. 2014-2026
Scientific journal article - peer reviewed
2015
Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans.
Martin Adiels, Adil Mardinoglu, Marja-Riitta Taskinen et al
Frontiers in Physiology. Vol. 6, p. 342
Scientific journal article - peer reviewed
2015
The gut microbiota modulates host amino acid and glutathione metabolism in mice
Adil Mardinoglu, Saeed Shoaie, Mattias Bergentall et al
Molecular Systems Biology. Vol. 11 (10), p. Article Number: 834
Scientific journal article - peer reviewed
2015
New paradigms for metabolic modeling of human cells
Adil Mardinoglu, Jens B. Nielsen,
Current Opinion in Biotechnology. Vol. 34, p. 91-97
Scientific journal article - peer reviewed
2015
Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue
Adil Mardinoglu, J. T. Heiker, D. Gartner et al
Scientific Reports. Vol. 5, p. 14841
Scientific journal article - peer reviewed
2015
Logical transformation of genome-scale metabolic models for gene level applications and analysis
Cheng Zhang, Boyang Ji, Adil Mardinoglu et al
Bioinformatics. Vol. 31 (14), p. 2324-2331
Scientific journal article - peer reviewed
2015
Tissue-based map of the human proteome
M. Uhlén, L. Fagerberg, B.M. Hallström et al
Science. Vol. 347 (6220), p. 394-
Scientific journal article - peer reviewed
2015
Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome
Saeed Shoaie, Pouyan Ghaffari Nouran, P. Kovatcheva-Datchary et al
Cell Metabolism. Vol. 22 (2), p. 320-331
Scientific journal article - peer reviewed
2015
The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling
C. Lindskog, J. Linne, L. Fagerberg et al
BMC Genomics. Vol. 16
Scientific journal article - peer reviewed
2015
Modelling the effect of spion size in a stent assisted magnetic drug targeting system with interparticle interactions
Adil Mardinoglu, P.J. Cregg,
Scientific World Journal. Vol. 2015
Scientific journal article - peer reviewed
2015
Proteome- and Transcriptome-Driven Reconstruction of the Human Myocyte Metabolic Network and Its Use for Identification of Markers for Diabetes
Leif Väremo, C. Scheele, C. Broholm et al
Cell Reports. Vol. 11 (6), p. 921-933
Scientific journal article - peer reviewed
2015
Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling
Pouyan Ghaffari Nouran, Adil Mardinoglu, A. Asplund et al
Scientific Reports. Vol. 5, p. Art. no. 8183
Scientific journal article - peer reviewed
2014
The use of Genome-scale metabolic models for drug target and biomarker identification
Adil Mardinoglu, M. Uhlen, Jens B. Nielsen et al
New Biotechnology. Vol. 31, p. S49-S49
Scientific journal article - non peer reviewed
2014
Toxicogenomics directory of chemically exposed human hepatocytes
Marianna Grinberg, Regina M. Stoeber, Karolina Edlund et al
ARCHIVES OF TOXICOLOGY. Vol. 88 (12), p. 2261-2287
Scientific journal article - peer reviewed
2014
Defining the Human Adipose Tissue Proteome To Reveal Metabolic Alterations in Obesity
Adil Mardinoglu, C. Kampf, A. Asplund et al
Journal of Proteome Research. Vol. 13 (11), p. 5106-5119
Scientific journal article - peer reviewed
2014
Defining the human gallbladder proteome by transcriptomics and affinity proteomics
C. Kampf, Adil Mardinoglu, L. Fagerberg et al
Proteomics. Vol. 14 (21-22), p. 2498-2507
Scientific journal article - peer reviewed
2014
The human liver-specific proteome defined by transcriptomics and antibody-based profiling
C. Kampf, Adil Mardinoglu, L. Fagerberg et al
Faseb Journal. Vol. 28 (7), p. 2901-2914
Scientific journal article - peer reviewed
2014
Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling
Rasmus Ågren, Adil Mardinoglu, A. Asplund et al
Molecular Systems Biology. Vol. 10 (3)
Scientific journal article - peer reviewed
2014
Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics
L. Fagerberg, B. M. Hallstrom, P. Oksvold et al
Molecular & Cellular Proteomics. Vol. 13 (2), p. 397-406
Scientific journal article - peer reviewed
2014
Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease
Adil Mardinoglu, Rasmus Ågren, C. Kampf et al
Nature Communications. Vol. 5, p. 11
Scientific journal article - peer reviewed
2013
Understanding the interactions between bacteria in the human gut through metabolic modeling
Saeed Shoaie, Fredrik H. Karlsson, Adil Mardinoglu et al
Scientific Reports. Vol. 3
Scientific journal article - peer reviewed
2013
Genome-scale modeling of human metabolism - a systems biology approach.
Adil Mardinoglu, Francesco Gatto, Jens B. Nielsen et al
Biotechnology Journal. Vol. 8
Scientific journal article - peer reviewed
2013
Integration of clinical data with a genome-scale metabolic model of the human adipocyte
Adil Mardinoglu, Rasmus Ågren, C. Kampf et al
Molecular Systems Biology. Vol. 9, p. 649
Scientific journal article - peer reviewed
2012
Reconstruction of Genome-Scale Active Metabolic Networks for 69 Human Cell Types and 16 Cancer Types Using INIT
Rasmus Ågren, Sergio Bordel Velasco, Adil Mardinoglu et al
PLoS Computational Biology
Scientific journal article - peer reviewed
2012
Systems medicine and metabolic modelling
Adil Mardinoglu, Jens B. Nielsen,
Journal of Internal Medicine. Vol. 271 (2), p. 142-154
Scientific journal article - peer reviewed
2012
Inclusion of interactions in mathematical modelling of implant assisted magnetic drug targeting
P. J. Cregg, K. Murphy, Adil Mardinoglu et al
Applied Mathematical Modelling. Vol. 36 (1), p. 1-34
Scientific journal article - peer reviewed
2011
Development of artificial neuronal networks for molecular communication
Adil Mardinoglu,
Nano Communication Networks. Vol. 2 (2-3), p. 150-160
Scientific journal article - peer reviewed
2011
Theoretical modelling of physiologically stretched vessel in magnetisable stent assisted magnetic drug targetingapplication
Adil Mardinoglu,
Journal of Magnetism and Magnetic Materials. Vol. 323 (3-4), p. 324-329
Scientific journal article - peer reviewed
2011
Artificial backbone neuronal network for nano scale sensors
F. Walsh, N.T. Boyle, Adil Mardinoglu et al
2011 IEEE Conference on Computer Communications Workshops, INFOCOM WKSHPS 2011. Shanghai, 10-15 April 2011, p. 449-454
Conference paper - peer reviewed
2010
Many particle magnetic dipole–dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting
Adil Mardinoglu,
Journal of Magnetism and Magnetic Materials. Vol. 322 (15), p. 2087-2094
Scientific journal article - peer reviewed
2009
Inclusion of magnetic dipole–dipole and hydrodynamic interactions in implant-assisted magnetic drug targeting
Adil Mardinoglu,
Journal of Magnetism and Magnetic Materials. Vol. 321 (23), p. 3893-3898
Scientific journal article - peer reviewed
2008
Calculation of nanoparticle capture efficiency in magnetic drug targeting
Adil Mardinoglu,
Journal of Magnetism and Magnetic Materials. Vol. 320 (23), p. 3272-3275
Scientific journal article - peer reviewed