Adil Mardinoglu
Showing 75 publications
2019
Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning
Beste Turanli, C. Zhang, Woonghee Kim et al
EBioMedicine
Journal article
2019
Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function
Zhengtao Liu, C. Zhang, Sunjae Lee et al
Metabolic Engineering. Vol. 52, p. 263-272
Journal article
2018
Metabolic Network-Based Identification and Prioritization o f Anticancer Targets Based on Expression Data in Hepatocellular Carcinoma
Gholamreza Bidkhori, Rui Benfeitas, Ezgi Elmas et al
Frontiers in Physiology. Vol. 9
Journal article
2018
Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes
G. Bidkhori, Rui Benfeitas, M. Klevstig et al
Proceedings of the National Academy of Sciences of the United States of America. Vol. 115 (50), p. E11874-E11883
Journal article
2018
Meta-Analysis of Adiponectin as a Biomarker for the Detection of Metabolic Syndrome
Zhengtao Liu, Shuheng Liang, Shuping Que et al
Frontiers in Physiology. Vol. 9
Review article
2018
Broad Views of Non-alcoholic Fatty Liver Disease
Adil Mardinoglu, Mathias Uhlen, Jan Borén
Cell Systems. Vol. 6 (1), p. 37-51.e9
Introductory text in journal
2018
Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes
Adil Mardinoglu, Silvia Gogg, Luca A. Lotta et al
EBioMedicine. Vol. 27, p. 151-155
Journal article
2018
Drug Repositioning for Effective Prostate Cancer Treatment
Beste Turanli, Morten Grötli, Jan Boren et al
Frontiers in Physiology. Vol. 9
Journal article
2018
Letter: dose-response analysis revealed closer relationship between obesity and perioperative outcomes in patients after liver transplantation
Zhengtao Liu, Adil Mardinoglu, S. P. Que
Alimentary Pharmacology and Therapeutics. Vol. 47 (2), p. 310-312
Introductory text in journal
2018
Systems biology in hepatology: Approaches and applications
Adil Mardinoglu, Jan Borén, Ulf Smith et al
Nature Reviews Gastroenterology and Hepatology. Vol. 15 (6), p. 365-377
Review article
2018
A Network-Based Cancer Drug Discovery: From Integrated Multi-Omics Approaches to Precision Medicine
Beste Turanli, Kubra Karagoz, Gizem Gulfidan et al
Current Pharmaceutical Design. Vol. 24 (32), p. 3778-3790
Review article
2018
An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans
Adil Mardinoglu, Hao Wu, Elias Björnson et al
Cell Metabolism. Vol. 27 (3), p. 559-571.e5
Journal article
2018
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome
Alen Lovric, Marit Granér, Elias Björnson et al
Scientific Reports. Vol. 8 (1)
Journal article
2018
Understanding the representative gut microbiota dysbiosis in metformin-treated Type 2 diabetes patients using genome-scale metabolic modeling
Dorines Rosario, Rui Benfeitas, G. Bidkhori et al
Frontiers in Physiology. Vol. 9
Journal article
2018
TCSBN: A database of tissue and cancer specific biological networks
Sunjae Lee, C. Zhang, M. Arif et al
Nucleic Acids Research. Vol. 46 (D1), p. D595-D600
Journal article
2018
Identification of discriminating metabolic pathways and metabolites in human PBMCs stimulated by various pathogenic agents
Xiang Zhang, Adil Mardinoglu, Leo A.B. Joosten et al
Frontiers in Physiology. Vol. 9 (FEB)
Journal article
2018
Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma
Jutta Huvila, Teemu D. Laajala, P. H. Edqvist et al
Gynecologic Oncology. Vol. 149 (1), p. 173-180
Journal article
2017
The effect of the TM6SF2 E167K variant on liver steatosis and fibrosis in patients with chronic hepatitis C: a meta-analysis
Z. T. Liu, S. P. Que, L. Zhou et al
Scientific Reports. Vol. 7 (1), p. 9273-
Journal article
2017
New challenges to study heterogeneity in cancer redox metabolism
Rui Benfeitas, Mathias Uhlen, Jens B Nielsen et al
Frontiers in Cell and Developmental Biology. Vol. 5 (JUL)
Journal article
2017
Predicting growth of the healthy infant using a genome scale metabolic model.
Avlant Nilsson, Adil Mardinoglu, Jens B Nielsen
NPJ systems biology and applications. Vol. 3, p. 3-
Journal article
2017
Rediscussion on Linearity Between Fibrosis Stages and Mortality Risk in Nonalcoholic Fatty Liver Disease Patients
Z. T. Liu, Shuping Que, Adil Mardinoglu
Hepatology. Vol. 66 (4), p. 1357-1358
Journal article
2017
Personal model-assisted identification of NAD(+) and glutathione metabolism as intervention target in NAFLD
Adil Mardinoglu, Elias Björnson, C. Zhang et al
Molecular Systems Biology. Vol. 13 (3)
Journal article
2017
Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease
Adil Mardinoglu, A. Stancakova, L. A. Lotta et al
Cell Metabolism. Vol. 26 (2), p. 281-283
Journal article
2017
Network analyses identify liver-specific targets for treating liver diseases
SangWook Lee, C. Zhang, Z. T. Liu et al
Molecular Systems Biology. Vol. 13 (8)
Journal article
2017
Selection of complementary foods based on optimal nutritional values
Partho Sen, Adil Mardinoglu, Jens B Nielsen
Scientific Reports. Vol. 7 (1), p. Article no 5413 -
Journal article
2017
A pathology atlas of the human cancer transcriptome
M. Uhlen, C. Zhang, SangWook Lee et al
Science. Vol. 357 (6352), p. 660-+
Journal article
2017
VIMENTIN DEFICIENCY IN MACROPHAGES INDUCES CD36-MEDIATED INFLAMMATION
Liliana Håversen, Marcus Ståhlman, Lillemor Mattsson Hultén et al
Atherosclerosis. Vol. 263, p. E87-E88
Conference contribution
2017
Improving the economics of NASH/NAFLD treatment through the use of systems biology
J. Bosley, C. Boren, SangWook Lee et al
Drug Discovery Today. Vol. 22 (10), p. 1532-1538
Journal article
2017
Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins
S. Heinonen, M. Muniandy, J. Buzkova et al
Diabetologia. Vol. 60 (1), p. 169-181
Journal article
2017
AUP1 (Ancient Ubiquitous Protein 1): A Molecular Link Between Hepatic Lipid Mobilization and VLDL Secretion
Adil Mardinoglu, Jan Borén
Arteriosclerosis, Thrombosis, and Vascular Biology. Vol. 37 (4), p. 609-610
Magazine article
2016
Editorial: The Impact of Systems Medicine on Human Health and Disease
Adil Mardinoglu, Jens B Nielsen
Frontiers in Physiology. Vol. 7 (NOV)
Magazine article
2016
Confounding effects of metformin on the human gut microbiome in Type 2 diabetes
Adil Mardinoglu, Jan Borén, Ulf Smith
Cell Metabolism. Vol. 23 (1), p. 10-12
Journal article
2016
Investigating the Combinatory Effects of Biological Networks on Gene Co-expression
C. Zhang, SangWook Lee, Adil Mardinoglu et al
Frontiers in Physiology. Vol. 7 (MAY)
Journal article
2016
Transcriptomics resources of human tissues and organs
M. Uhlen, B. M. Hallstrom, C. Lindskog et al
Molecular Systems Biology. Vol. 12 (4)
Journal article
2016
Adaptive Evolution of Phosphorus Metabolism in Prochlorococcus.
John R Casey, Adil Mardinoglu, Jens B Nielsen et al
mSystems. Vol. 1 (6), p. Article no UNSP e00065 -
Journal article
2016
Phenotypic and genetic variance: a systems approach to the liver
Adil Mardinoglu, M. Uhlen
Nature Reviews Gastroenterology and Hepatology. Vol. 13 (8), p. 439-440
Magazine article
2016
Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance
SangWook Lee, C. Zhang, M. Kilicarslan et al
Cell Metabolism. Vol. 24 (1), p. 172-184
Journal article
2016
ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism
Aditi Chaudhari, Liliana Håversen, Reza Mobini et al
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. Vol. 1861 (11), p. 1643-1651
Journal article
2016
Personalized Cardiovascular Disease Prediction and Treatment-A Review of Existing Strategies and Novel Systems Medicine Tools
Elias Björnson, Jan Borén, Adil Mardinoglu
Frontiers in Physiology. Vol. 7 (JAN)
Journal article
2016
Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism
Ibrahim El-Semman, Adil Mardinoglu, Saeed Shoaie et al
Molecular BioSystems. Vol. 12 (5), p. 1496-1506
Journal article
2016
Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis
SangWook Lee, Adil Mardinoglu, C. Zhang et al
Nucleic Acids Research. Vol. 44 (12), p. 5529-5539
Journal article
2016
Integrated Network Modeling for Novel Target Searches and Better Predictive Models
Adil Mardinoglu, J. Bosley
Journal of Pharmacokinetics and Pharmacodynamics. Vol. 43, p. S88-S88
Conference contribution
2015
The gut microbiota modulates host amino acid and glutathione metabolism in mice
Adil Mardinoglu, Saeed Shoaie, Mattias Bergentall et al
Molecular Systems Biology. Vol. 11 (10), p. Article Number: 834-
Journal article
2015
Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue
Adil Mardinoglu, J. T. Heiker, D. Gartner et al
Scientific Reports. Vol. 5, p. 14841-
Journal article
2015
Logical transformation of genome-scale metabolic models for gene level applications and analysis
C. Zhang, Boyang Ji, Adil Mardinoglu et al
Bioinformatics. Vol. 31 (14), p. 2324-2331
Journal article
2015
Cancer Metabolism: A Modeling Perspective
Pouyan Ghaffari Nouran, Adil Mardinoglu, Jens B Nielsen
Frontiers in Physiology. Vol. 6 (DEC)
Journal article
2015
Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome
Saeed Shoaie, Pouyan Ghaffari Nouran, P. Kovatcheva-Datchary et al
Cell Metabolism. Vol. 22 (2), p. 320-331
Journal article
2015
Tissue-based map of the human proteome
M. Uhlen, L. Fagerberg, B.M. Hallström et al
Science. Vol. 347 (6220), p. 394-
Journal article
2015
The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling
C. Lindskog, J. Linne, L. Fagerberg et al
BMC Genomics. Vol. 16 (1)
Journal article
2015
New paradigms for metabolic modeling of human cells
Adil Mardinoglu, Jens B Nielsen
Current Opinion in Biotechnology. Vol. 34, p. 91-97
Journal article
2015
Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization
Elias Björnson, B. Mukhopadhyay, A. Asplund et al
Cell Reports. Vol. 13 (9), p. 2014-2026
Journal article
2015
Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling
Pouyan Ghaffari Nouran, Adil Mardinoglu, A. Asplund et al
Scientific Reports. Vol. 5, p. Art. no. 8183-
Journal article
2015
Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans.
Martin Adiels, Adil Mardinoglu, Marja-Riitta Taskinen et al
Frontiers in Physiology. Vol. 6 (NOV), p. 342-
Journal article
2015
Modelling the effect of spion size in a stent assisted magnetic drug targeting system with interparticle interactions
Adil Mardinoglu, P. J. Cregg
The Scientific World Journal. Vol. 2015
Journal article
2015
Proteome- and Transcriptome-Driven Reconstruction of the Human Myocyte Metabolic Network and Its Use for Identification of Markers for Diabetes
Leif Wigge, C. Scheele, C. Broholm et al
Cell Reports. Vol. 11 (6), p. 921-933
Journal article
2014
Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling
Rasmus Ågren, Adil Mardinoglu, A. Asplund et al
Molecular Systems Biology. Vol. 10 (3)
Journal article
2014
Defining the Human Adipose Tissue Proteome To Reveal Metabolic Alterations in Obesity
Adil Mardinoglu, C. Kampf, A. Asplund et al
Journal of Proteome Research. Vol. 13 (11), p. 5106-5119
Journal article
2014
Toxicogenomics directory of chemically exposed human hepatocytes
Marianna Grinberg, Regina M. Stoeber, K. Edlund et al
Archives of Toxicology. Vol. 88 (12), p. 2261-2287
Journal article
2014
Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics
L. Fagerberg, B. M. Hallstrom, P. Oksvold et al
Molecular and Cellular Proteomics. Vol. 13 (2), p. 397-406
Journal article
2014
The use of Genome-scale metabolic models for drug target and biomarker identification
Adil Mardinoglu, M. Uhlen, Jens B Nielsen
New Biotechnology. Vol. 31, p. S49-S49
Magazine article
2014
The human liver-specific proteome defined by transcriptomics and antibody-based profiling
C. Kampf, Adil Mardinoglu, L. Fagerberg et al
FASEB Journal. Vol. 28 (7), p. 2901-2914
Journal article
2014
Defining the human gallbladder proteome by transcriptomics and affinity proteomics
C. Kampf, Adil Mardinoglu, L. Fagerberg et al
Proteomics. Vol. 14 (21-22), p. 2498-2507
Journal article
2014
Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease
Adil Mardinoglu, Rasmus Ågren, C. Kampf et al
Nature Communications. Vol. 5, p. 11-
Journal article
2013
Genome-scale modeling of human metabolism - a systems biology approach.
Adil Mardinoglu, Francesco Gatto, Jens B Nielsen
Biotechnology journal. Vol. 8
Journal article
2013
Integration of clinical data with a genome-scale metabolic model of the human adipocyte
Adil Mardinoglu, Rasmus Ågren, C. Kampf et al
Molecular Systems Biology. Vol. 9 (1), p. 649-
Journal article
2013
Understanding the interactions between bacteria in the human gut through metabolic modeling
Saeed Shoaie, Fredrik Karlsson, Adil Mardinoglu et al
Scientific Reports. Vol. 3
Journal article
2012
Reconstruction of Genome-Scale Active Metabolic Networks for 69 Human Cell Types and 16 Cancer Types Using INIT
Rasmus Ågren, Sergio Velasco, Adil Mardinoglu et al
PLoS Computational Biology (5)
Journal article
2012
Inclusion of interactions in mathematical modelling of implant assisted magnetic drug targeting
P. J. Cregg, K. Murphy, Adil Mardinoglu
Applied Mathematical Modelling. Vol. 36 (1), p. 1-34
Journal article
2012
Systems medicine and metabolic modelling
Adil Mardinoglu, Jens B Nielsen
Journal of Internal Medicine. Vol. 271 (2), p. 142-154
Journal article
2011
Development of artificial neuronal networks for molecular communication
Adil Mardinoglu
Nano Communication Networks. Vol. 2 (2-3), p. 150-160
Journal article
2011
Artificial backbone neuronal network for nano scale sensors
F. Walsh, N.T. Boyle, Adil Mardinoglu et al
2011 IEEE Conference on Computer Communications Workshops, INFOCOM WKSHPS 2011. Shanghai, 10-15 April 2011, p. 449-454
Paper in proceedings
2011
Theoretical modelling of physiologically stretched vessel in magnetisable stent assisted magnetic drug targetingapplication
Adil Mardinoglu
Journal of Magnetism and Magnetic Materials. Vol. 323 (3-4), p. 324-329
Journal article
2010
Many particle magnetic dipole–dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting
Adil Mardinoglu
Journal of Magnetism and Magnetic Materials. Vol. 322 (15), p. 2087-2094
Journal article
2009
Inclusion of magnetic dipole–dipole and hydrodynamic interactions in implant-assisted magnetic drug targeting
Adil Mardinoglu
Journal of Magnetism and Magnetic Materials. Vol. 321 (23), p. 3893-3898
Journal article
2008
Calculation of nanoparticle capture efficiency in magnetic drug targeting
Adil Mardinoglu
Journal of Magnetism and Magnetic Materials. Vol. 320 (23), p. 3272-3275
Journal article
Showing 1 research projects
2014–2018
Integrating Modelling of Metabolism and Signalling towards an Application in Liver Cancer (ERASysAPP - IMOMESIC)
Jens B Nielsen
Biology and Biological Engineering
Avlant Nilsson
Systems and Synthetic Biology
Adil Mardinoglu
Systems and Synthetic Biology
Swedish Research Council (VR)
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