Adil Mardinoglu

Forskarassistent at Department of Biology and Biological Engineering, Systems and Synthetic Biology

Dr. Adil Mardinoglu works in Systems Biology group and his research is focused on the establishment of Human Metabolic Atlas (HMA), an interactive data analysis and model simulation platform. HMA platform employ systems biology approaches to elucidate some of the genes, metabolites and reactions that are underlying several complex diseases such as obesity and its adverse outcomes. Healthcare professionals and pharmaceutical developers may harvest and translate the outcomes of HMA platform into the benefit of patients, find new therapies and eventually determine more effective personalized medicine for variety of diseases.

Source: chalmers.se

Projects

2014–2018

Integrating Modelling of Metabolism and Signalling towards an Application in Liver Cancer (ERASysAPP - IMOMESIC)

Jens B Nielsen Department of Biology and Biological Engineering
Avlant Nilsson Department of Biology and Biological Engineering, Systems and Synthetic Biology
Adil Mardinoglu Department of Biology and Biological Engineering, Systems and Synthetic Biology
Swedish Research Council (VR)

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Publications

2017

Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins

S. Heinonen, M. Muniandy, J. Buzkova et al
Diabetologia. Vol. 60 (1), p. 169-181
Scientific journal article - peer reviewed
2016

Adaptive Evolution of Phosphorus Metabolism in Prochlorococcus.

John R Casey, Adil Mardinoglu, Jens B. Nielsen et al
mSystems. Vol. 1 (6)
Scientific journal article - peer reviewed
2016

Editorial: The Impact of Systems Medicine on Human Health and Disease

Adil Mardinoglu, Jens B. Nielsen,
Frontiers in Physiology. Vol. 7
Scientific journal article - non peer reviewed
2016

Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis

S. Lee, Adil Mardinoglu, C. Zhang et al
Nucleic Acids Research. Vol. 44 (12), p. 5529-5539
Scientific journal article - peer reviewed
2016

Phenotypic and genetic variance: a systems approach to the liver

Adil Mardinoglu, M. Uhlen,
Nature Reviews Gastroenterology & Hepatology. Vol. 13 (8), p. 439-440
Scientific journal article - non peer reviewed
2016

Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance

S. Lee, C. Zhang, M. Kilicarslan et al
Cell Metabolism. Vol. 24 (1), p. 172-184
Scientific journal article - peer reviewed
2016

ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism

Aditi Chaudhari, Liliana Håversen, Reza Mobini et al
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. Vol. 1861 (11), p. 1643-1651
Scientific journal article - peer reviewed
2016

Transcriptomics resources of human tissues and organs

M. Uhlen, B. M. Hallstrom, C. Lindskog et al
Molecular Systems Biology. Vol. 12 (4)
Scientific journal article - peer reviewed
2016

Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism

Ibrahim El-Semman, Adil Mardinoglu, Saeed Shoaie et al
Molecular Biosystems. Vol. 12 (5), p. 1496-1506
Scientific journal article - peer reviewed
2016

Investigating the Combinatory Effects of Biological Networks on Gene Co-expression

C. Zhang, S. Lee, Adil Mardinoglu et al
Frontiers in Physiology. Vol. 7
Scientific journal article - peer reviewed
2016

Confounding effects of metformin on the human gut microbiome in Type 2 diabetes

Adil Mardinoglu, Jan Borén, Ulf Smith et al
Cell Metabolism. Vol. 23 (1), p. 10-12
Scientific journal article - peer reviewed
2016

Personalized Cardiovascular Disease Prediction and Treatment-A Review of Existing Strategies and Novel Systems Medicine Tools

Elias Björnson, J. Boren, Adil Mardinoglu et al
Frontiers in Physiology. Vol. 7
Scientific journal article - peer reviewed
2015

Cancer Metabolism: A Modeling Perspective

Pouyan Ghaffari Nouran, Adil Mardinoglu, Jens B. Nielsen et al
Frontiers in Physiology. Vol. 6
Scientific journal article - peer reviewed
2015

Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization

Elias Björnson, B. Mukhopadhyay, A. Asplund et al
Cell Reports. Vol. 13 (9), p. 2014-2026
Scientific journal article - peer reviewed
2015

Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans.

Martin Adiels, Adil Mardinoglu, Marja-Riitta Taskinen et al
Frontiers in Physiology. Vol. 6, p. 342
Scientific journal article - peer reviewed
2015

The gut microbiota modulates host amino acid and glutathione metabolism in mice

Adil Mardinoglu, Saeed Shoaie, Mattias Bergentall et al
Molecular Systems Biology. Vol. 11 (10), p. Article Number: 834
Scientific journal article - peer reviewed
2015

New paradigms for metabolic modeling of human cells

Adil Mardinoglu, Jens B. Nielsen,
Current Opinion in Biotechnology. Vol. 34, p. 91-97
Scientific journal article - peer reviewed
2015

Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue

Adil Mardinoglu, J. T. Heiker, D. Gartner et al
Scientific Reports. Vol. 5, p. 14841
Scientific journal article - peer reviewed
2015

Logical transformation of genome-scale metabolic models for gene level applications and analysis

Cheng Zhang, Boyang Ji, Adil Mardinoglu et al
Bioinformatics. Vol. 31 (14), p. 2324-2331
Scientific journal article - peer reviewed
2015

Tissue-based map of the human proteome

M. Uhlén, L. Fagerberg, B.M. Hallström et al
Science. Vol. 347 (6220), p. 394-
Scientific journal article - peer reviewed
2015

Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome

Saeed Shoaie, Pouyan Ghaffari Nouran, P. Kovatcheva-Datchary et al
Cell Metabolism. Vol. 22 (2), p. 320-331
Scientific journal article - peer reviewed
2015

The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling

C. Lindskog, J. Linne, L. Fagerberg et al
BMC Genomics. Vol. 16
Scientific journal article - peer reviewed
2015

Modelling the effect of spion size in a stent assisted magnetic drug targeting system with interparticle interactions

Adil Mardinoglu, P.J. Cregg,
Scientific World Journal. Vol. 2015
Scientific journal article - peer reviewed
2015

Proteome- and Transcriptome-Driven Reconstruction of the Human Myocyte Metabolic Network and Its Use for Identification of Markers for Diabetes

Leif Väremo, C. Scheele, C. Broholm et al
Cell Reports. Vol. 11 (6), p. 921-933
Scientific journal article - peer reviewed
2015

Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling

Pouyan Ghaffari Nouran, Adil Mardinoglu, A. Asplund et al
Scientific Reports. Vol. 5, p. Art. no. 8183
Scientific journal article - peer reviewed
2014

The use of Genome-scale metabolic models for drug target and biomarker identification

Adil Mardinoglu, M. Uhlen, Jens B. Nielsen et al
New Biotechnology. Vol. 31, p. S49-S49
Scientific journal article - non peer reviewed
2014

Toxicogenomics directory of chemically exposed human hepatocytes

Marianna Grinberg, Regina M. Stoeber, Karolina Edlund et al
ARCHIVES OF TOXICOLOGY. Vol. 88 (12), p. 2261-2287
Scientific journal article - peer reviewed
2014

Defining the Human Adipose Tissue Proteome To Reveal Metabolic Alterations in Obesity

Adil Mardinoglu, C. Kampf, A. Asplund et al
Journal of Proteome Research. Vol. 13 (11), p. 5106-5119
Scientific journal article - peer reviewed
2014

Defining the human gallbladder proteome by transcriptomics and affinity proteomics

C. Kampf, Adil Mardinoglu, L. Fagerberg et al
Proteomics. Vol. 14 (21-22), p. 2498-2507
Scientific journal article - peer reviewed
2014

The human liver-specific proteome defined by transcriptomics and antibody-based profiling

C. Kampf, Adil Mardinoglu, L. Fagerberg et al
Faseb Journal. Vol. 28 (7), p. 2901-2914
Scientific journal article - peer reviewed
2014

Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling

Rasmus Ågren, Adil Mardinoglu, A. Asplund et al
Molecular Systems Biology. Vol. 10 (3)
Scientific journal article - peer reviewed
2014

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

L. Fagerberg, B. M. Hallstrom, P. Oksvold et al
Molecular & Cellular Proteomics. Vol. 13 (2), p. 397-406
Scientific journal article - peer reviewed
2014

Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease

Adil Mardinoglu, Rasmus Ågren, C. Kampf et al
Nature Communications. Vol. 5, p. 11
Scientific journal article - peer reviewed
2013

Understanding the interactions between bacteria in the human gut through metabolic modeling

Saeed Shoaie, Fredrik H. Karlsson, Adil Mardinoglu et al
Scientific Reports. Vol. 3
Scientific journal article - peer reviewed
2013

Genome-scale modeling of human metabolism - a systems biology approach.

Adil Mardinoglu, Francesco Gatto, Jens B. Nielsen et al
Biotechnology Journal. Vol. 8
Scientific journal article - peer reviewed
2013

Integration of clinical data with a genome-scale metabolic model of the human adipocyte

Adil Mardinoglu, Rasmus Ågren, C. Kampf et al
Molecular Systems Biology. Vol. 9, p. 649
Scientific journal article - peer reviewed
2012

Reconstruction of Genome-Scale Active Metabolic Networks for 69 Human Cell Types and 16 Cancer Types Using INIT

Rasmus Ågren, Sergio Bordel Velasco, Adil Mardinoglu et al
PLoS Computational Biology
Scientific journal article - peer reviewed
2012

Systems medicine and metabolic modelling

Adil Mardinoglu, Jens B. Nielsen,
Journal of Internal Medicine. Vol. 271 (2), p. 142-154
Scientific journal article - peer reviewed
2012

Inclusion of interactions in mathematical modelling of implant assisted magnetic drug targeting

P. J. Cregg, K. Murphy, Adil Mardinoglu et al
Applied Mathematical Modelling. Vol. 36 (1), p. 1-34
Scientific journal article - peer reviewed
2011

Development of artificial neuronal networks for molecular communication

Adil Mardinoglu,
Nano Communication Networks. Vol. 2 (2-3), p. 150-160
Scientific journal article - peer reviewed
2011

Theoretical modelling of physiologically stretched vessel in magnetisable stent assisted magnetic drug targetingapplication

Adil Mardinoglu,
Journal of Magnetism and Magnetic Materials. Vol. 323 (3-4), p. 324-329
Scientific journal article - peer reviewed
2011

Artificial backbone neuronal network for nano scale sensors

F. Walsh, N.T. Boyle, Adil Mardinoglu et al
2011 IEEE Conference on Computer Communications Workshops, INFOCOM WKSHPS 2011. Shanghai, 10-15 April 2011, p. 449-454
Conference paper - peer reviewed
2010

Many particle magnetic dipole–dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting

Adil Mardinoglu,
Journal of Magnetism and Magnetic Materials. Vol. 322 (15), p. 2087-2094
Scientific journal article - peer reviewed
2009

Inclusion of magnetic dipole–dipole and hydrodynamic interactions in implant-assisted magnetic drug targeting

Adil Mardinoglu,
Journal of Magnetism and Magnetic Materials. Vol. 321 (23), p. 3893-3898
Scientific journal article - peer reviewed
2008

Calculation of nanoparticle capture efficiency in magnetic drug targeting

Adil Mardinoglu,
Journal of Magnetism and Magnetic Materials. Vol. 320 (23), p. 3272-3275
Scientific journal article - peer reviewed