Adil Mardinoglu

Systems biology based drug repositioning for development of cancer therapy

A systems biology approach for studying neurodegenerative diseases

2020

Current Status of COVID-19 Therapies and Drug Repositioning Applications

2020

MEMOTE for standardized genome-scale metabolic model testing

Improvement in the Current Therapies for Hepatocellular Carcinoma Using a Systems Medicine Approach

2020

Classification of clear cell renal cell carcinoma based on PKM alternative splicing

Pivotal role of micronucleus test in drug discovery

Plasma Proteomics Analysis Reveals Dysregulation of Complement Proteins and Inflammation in Acquired Obesity—A Study on Rare BMI-Discordant Monozygotic Twin Pairs

2019

Elucidating the Reprograming of Colorectal Cancer Metabolism Using Genome-Scale Metabolic Modeling

Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis

2019

Systems biology perspective for studying the gut microbiota in human physiology and liver diseases

Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning

2019

Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia

LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer

Multi-Omic Data Interpretation to Repurpose Subtype Specific Drug Candidates for Breast Cancer

Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function

2018

Metabolic Network-Based Identification and Prioritization o f Anticancer Targets Based on Expression Data in Hepatocellular Carcinoma

2018

Meta-Analysis of Adiponectin as a Biomarker for the Detection of Metabolic Syndrome

Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes

Broad Views of Non-alcoholic Fatty Liver Disease

2018

Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes

2018

Drug Repositioning for Effective Prostate Cancer Treatment

Letter: dose-response analysis revealed closer relationship between obesity and perioperative outcomes in patients after liver transplantation

2018

ESS: A Tool for Genome-Scale Quantification of Essentiality Score for Reaction/Genes in Constraint-Based Modeling

Systems biology in hepatology: Approaches and applications

A Network-Based Cancer Drug Discovery: From Integrated Multi-Omics Approaches to Precision Medicine

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans

2018

Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome

2018

Understanding the representative gut microbiota dysbiosis in metformin-treated Type 2 diabetes patients using genome-scale metabolic modeling

2018

TCSBN: A database of tissue and cancer specific biological networks

2018

Identification of discriminating metabolic pathways and metabolites in human PBMCs stimulated by various pathogenic agents

Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma

2017

The effect of the TM6SF2 E167K variant on liver steatosis and fibrosis in patients with chronic hepatitis C: a meta-analysis

2017

New challenges to study heterogeneity in cancer redox metabolism

Predicting growth of the healthy infant using a genome scale metabolic model.

Rediscussion on Linearity Between Fibrosis Stages and Mortality Risk in Nonalcoholic Fatty Liver Disease Patients

2017

Personal model-assisted identification of NAD(+) and glutathione metabolism as intervention target in NAFLD

Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease

2017

Network analyses identify liver-specific targets for treating liver diseases

2017

Selection of complementary foods based on optimal nutritional values

A pathology atlas of the human cancer transcriptome

VIMENTIN DEFICIENCY IN MACROPHAGES INDUCES CD36-MEDIATED INFLAMMATION

Improving the economics of NASH/NAFLD treatment through the use of systems biology

Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins

AUP1 (Ancient Ubiquitous Protein 1): A Molecular Link Between Hepatic Lipid Mobilization and VLDL Secretion

2016

Editorial: The Impact of Systems Medicine on Human Health and Disease

Confounding effects of metformin on the human gut microbiome in Type 2 diabetes

2016

Investigating the Combinatory Effects of Biological Networks on Gene Co-expression

2016

Adaptive Evolution of Phosphorus Metabolism in Prochlorococcus.

2016

Transcriptomics resources of human tissues and organs

Phenotypic and genetic variance: a systems approach to the liver

Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance

ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism

2016

Personalized Cardiovascular Disease Prediction and Treatment-A Review of Existing Strategies and Novel Systems Medicine Tools

Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism

2016

Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis

Integrated Network Modeling for Novel Target Searches and Better Predictive Models

2015

The gut microbiota modulates host amino acid and glutathione metabolism in mice

2015

Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue

Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome

2015

Cancer Metabolism: A Modeling Perspective

Logical transformation of genome-scale metabolic models for gene level applications and analysis

Tissue-based map of the human proteome

2015

The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling

New paradigms for metabolic modeling of human cells

2015

Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization

2015

Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling

2015

Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans.

2015

Modelling the effect of spion size in a stent assisted magnetic drug targeting system with interparticle interactions

2015

Proteome- and Transcriptome-Driven Reconstruction of the Human Myocyte Metabolic Network and Its Use for Identification of Markers for Diabetes

2014

Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling

Defining the Human Adipose Tissue Proteome To Reveal Metabolic Alterations in Obesity

Toxicogenomics directory of chemically exposed human hepatocytes

The use of Genome-scale metabolic models for drug target and biomarker identification

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

The human liver-specific proteome defined by transcriptomics and antibody-based profiling

Defining the human gallbladder proteome by transcriptomics and affinity proteomics

Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease

Genome-scale modeling of human metabolism - a systems biology approach.

2013

Integration of clinical data with a genome-scale metabolic model of the human adipocyte

2013

Understanding the interactions between bacteria in the human gut through metabolic modeling

2012

Reconstruction of Genome-Scale Active Metabolic Networks for 69 Human Cell Types and 16 Cancer Types Using INIT

Inclusion of interactions in mathematical modelling of implant assisted magnetic drug targeting

Systems medicine and metabolic modelling

Development of artificial neuronal networks for molecular communication

Artificial backbone neuronal network for nano scale sensors

Theoretical modelling of physiologically stretched vessel in magnetisable stent assisted magnetic drug targetingapplication

Many particle magnetic dipole–dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting

Inclusion of magnetic dipole–dipole and hydrodynamic interactions in implant-assisted magnetic drug targeting

Calculation of nanoparticle capture efficiency in magnetic drug targeting