Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis
Journal article, 2016

Hepatocellular carcinoma (HCC) has a high mortality rate and early detection of HCC is crucial for the application of effective treatment strategies. HCC is typically caused by either viral hepatitis infection or by fatty liver disease. To diagnose and treat HCC it is necessary to elucidate the underlying molecular mechanisms. As a major cause for development of HCC is fatty liver disease, we here investigated anomalies in regulation of lipid metabolism in the liver. We applied a tailored network-based approach to identify signaling hubs associated with regulation of this part of metabolism. Using transcriptomics data of HCC patients, we identified significant dysregulated expressions of lipid-regulated genes, across many different lipid metabolic pathways. Our findings, however, show that viral hepatitis causes HCC by a distinct mechanism, less likely involving lipid anomalies. Based on our analysis we suggest signaling hub genes governing overall catabolic or anabolic pathways, as novel drug targets for treatment of HCC that involves lipid anomalies.

Author

SangWook Lee

Korea Advanced Institute of Science and Technology

Royal Institute of Technology (KTH)

Adil Mardinoglu

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

C. Zhang

Royal Institute of Technology (KTH)

D. Lee

Korea Advanced Institute of Science and Technology

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Nucleic Acids Research

0305-1048 (ISSN) 1362-4962 (eISSN)

Vol. 44 12 5529-5539

Subject Categories

Biochemistry and Molecular Biology

Areas of Advance

Life Science Engineering (2010-2018)

DOI

10.1093/nar/gkw462

PubMed

27216817

More information

Latest update

2/26/2018