Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis
Artikel i vetenskaplig tidskrift, 2016

Hepatocellular carcinoma (HCC) has a high mortality rate and early detection of HCC is crucial for the application of effective treatment strategies. HCC is typically caused by either viral hepatitis infection or by fatty liver disease. To diagnose and treat HCC it is necessary to elucidate the underlying molecular mechanisms. As a major cause for development of HCC is fatty liver disease, we here investigated anomalies in regulation of lipid metabolism in the liver. We applied a tailored network-based approach to identify signaling hubs associated with regulation of this part of metabolism. Using transcriptomics data of HCC patients, we identified significant dysregulated expressions of lipid-regulated genes, across many different lipid metabolic pathways. Our findings, however, show that viral hepatitis causes HCC by a distinct mechanism, less likely involving lipid anomalies. Based on our analysis we suggest signaling hub genes governing overall catabolic or anabolic pathways, as novel drug targets for treatment of HCC that involves lipid anomalies.

Författare

SangWook Lee

Korea Advanced Institute of Science and Technology

Kungliga Tekniska Högskolan (KTH)

Adil Mardinoglu

Chalmers, Biologi och bioteknik, Systembiologi

C. Zhang

Kungliga Tekniska Högskolan (KTH)

D. Lee

Korea Advanced Institute of Science and Technology

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Nucleic Acids Research

0305-1048 (ISSN) 1362-4962 (eISSN)

Vol. 44 12 5529-5539

Ämneskategorier

Biokemi och molekylärbiologi

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1093/nar/gkw462

PubMed

27216817