Transcriptomics resources of human tissues and organs
Journal article, 2016

Quantifying the differential expression of genes in various human organs, tissues, and cell types is vital to understand human physiology and disease. Recently, several large-scale transcriptomics studies have analyzed the expression of protein-coding genes across tissues. These datasets provide a framework for defining the molecular constituents of the human body as well as for generating comprehensive lists of proteins expressed across tissues or in a tissue-restricted manner. Here, we review publicly available human transcriptome resources and discuss body-wide data from independent genome-wide transcriptome analyses of different tissues. Gene expression measurements from these independent datasets, generated using samples from fresh frozen surgical specimens and postmortem tissues, are consistent. Overall, the different genome-wide analyses support a distribution in which many proteins are found in all tissues and relatively few in a tissue-restricted manner. Moreover, we discuss the applications of publicly available omics data for building genome-scale metabolic models, used for analyzing cell and tissue functions both in physiological and in disease contexts.

proteomics

transcriptomics

genome-scale metabolic models

Author

M. Uhlen

Technical University of Denmark (DTU)

Royal Institute of Technology (KTH)

B. M. Hallstrom

Royal Institute of Technology (KTH)

C. Lindskog

Uppsala University

Adil Mardinoglu

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

F. Ponten

Uppsala University

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Molecular Systems Biology

1744-4292 (ISSN)

Vol. 12 4 862

Areas of Advance

Life Science Engineering (2010-2018)

Subject Categories

Bioinformatics and Systems Biology

DOI

10.15252/msb.20155865

More information

Latest update

2/28/2018