Transcriptomics resources of human tissues and organs
Artikel i vetenskaplig tidskrift, 2016

Quantifying the differential expression of genes in various human organs, tissues, and cell types is vital to understand human physiology and disease. Recently, several large-scale transcriptomics studies have analyzed the expression of protein-coding genes across tissues. These datasets provide a framework for defining the molecular constituents of the human body as well as for generating comprehensive lists of proteins expressed across tissues or in a tissue-restricted manner. Here, we review publicly available human transcriptome resources and discuss body-wide data from independent genome-wide transcriptome analyses of different tissues. Gene expression measurements from these independent datasets, generated using samples from fresh frozen surgical specimens and postmortem tissues, are consistent. Overall, the different genome-wide analyses support a distribution in which many proteins are found in all tissues and relatively few in a tissue-restricted manner. Moreover, we discuss the applications of publicly available omics data for building genome-scale metabolic models, used for analyzing cell and tissue functions both in physiological and in disease contexts.

proteomics

transcriptomics

genome-scale metabolic models

Författare

M. Uhlen

Danmarks Tekniske Universitet (DTU)

Kungliga Tekniska Högskolan (KTH)

B. M. Hallstrom

Kungliga Tekniska Högskolan (KTH)

C. Lindskog

Uppsala universitet

Adil Mardinoglu

Chalmers, Biologi och bioteknik, Systembiologi

F. Ponten

Uppsala universitet

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Molecular Systems Biology

1744-4292 (ISSN)

Vol. 12 4 862

Styrkeområden

Livsvetenskaper och teknik

Ämneskategorier

Bioinformatik och systembiologi

DOI

10.15252/msb.20155865

Mer information

Senast uppdaterat

2018-02-28