Systems biology perspective for studying the gut microbiota in human physiology and liver diseases
Review article, 2019

The advancement in high-throughput sequencing technologies and systems biology approaches have revolutionized our understanding of biological systems and opened a new path to investigate unacknowledged biological phenomena. In parallel, the field of human microbiome research has greatly evolved and the relative contribution of the gut microbiome to health and disease have been systematically explored. This review provides an overview of the network-based and translational systems biology-based studies focusing on the function and composition of gut microbiota. We also discussed the association between the gut microbiome and the overall human physiology, as well as hepatic diseases and other metabolic disorders.

Host-microbiome interactions

Metabolic models

Personalized medicine


Liver diseases

Systems biology


Gut microbiome


Ozlem Altay

Royal Institute of Technology (KTH)

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Mathias Uhlen

Royal Institute of Technology (KTH)

Jan Borén

Sahlgrenska University Hospital

Adil Mardinoglu

King's College London

Royal Institute of Technology (KTH)


2352-3964 (eISSN)

Vol. 49 November 363-373

Subject Categories

Information Science

Bioinformatics and Systems Biology

Information Systemes, Social aspects





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