Systems biology perspective for studying the gut microbiota in human physiology and liver diseases
Reviewartikel, 2019

The advancement in high-throughput sequencing technologies and systems biology approaches have revolutionized our understanding of biological systems and opened a new path to investigate unacknowledged biological phenomena. In parallel, the field of human microbiome research has greatly evolved and the relative contribution of the gut microbiome to health and disease have been systematically explored. This review provides an overview of the network-based and translational systems biology-based studies focusing on the function and composition of gut microbiota. We also discussed the association between the gut microbiome and the overall human physiology, as well as hepatic diseases and other metabolic disorders.

Liver diseases

Systems biology

Gut microbiome

Metabolic models

Host-microbiome interactions

Meta-omics

Personalized medicine

Biomarker

Författare

Ozlem Altay

Kungliga Tekniska Högskolan (KTH)

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Mathias Uhlen

Kungliga Tekniska Högskolan (KTH)

Jan Borén

Sahlgrenska universitetssjukhuset

Adil Mardinoglu

King's College London

Kungliga Tekniska Högskolan (KTH)

EBioMedicine

2352-3964 (eISSN)

Vol. In Press

Ämneskategorier

Systemvetenskap

Bioinformatik och systembiologi

Systemvetenskap, informationssystem och informatik med samhällsvetenskaplig inriktning

DOI

10.1016/j.ebiom.2019.09.057

PubMed

31636011

Mer information

Senast uppdaterat

2019-11-13