Calculation of nanoparticle capture efficiency in magnetic drug targeting
Journal article, 2008

The implant assisted magnetic targeted drug delivery system of Avilés, Ebner and Ritter, which uses high gradient magnetic separation (HGMS) is considered. In this 2D model large ferromagnetic particles are implanted as seeds to aid collection of multiple domain nanoparticles (radius ). Here, in contrast, single domain magnetic nanoparticles (radius in 20–100 nm) are considered and the Langevin function is used to describe the magnetization. Simulations based on this model were performed using the open source C++ finite volume library OpenFOAM. The simulations indicate that use of the Langevin function predicts greater collection efficiency than might be otherwise expected.

Magnetic seed

Simulation

Magnetic nanoparticle

Magnetic drug targeting

High gradient magnetic separation (HGMS)

Author

Adil Mardinoglu

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Journal of Magnetism and Magnetic Materials

Vol. 320 23 3272-3275

Areas of Advance

Life Science Engineering (2010-2018)

Subject Categories

Bioinformatics and Systems Biology

Public Health, Global Health, Social Medicine and Epidemiology

More information

Created

10/8/2017