Calculation of nanoparticle capture efficiency in magnetic drug targeting
Artikel i vetenskaplig tidskrift, 2008

The implant assisted magnetic targeted drug delivery system of Avilés, Ebner and Ritter, which uses high gradient magnetic separation (HGMS) is considered. In this 2D model large ferromagnetic particles are implanted as seeds to aid collection of multiple domain nanoparticles (radius ). Here, in contrast, single domain magnetic nanoparticles (radius in 20–100 nm) are considered and the Langevin function is used to describe the magnetization. Simulations based on this model were performed using the open source C++ finite volume library OpenFOAM. The simulations indicate that use of the Langevin function predicts greater collection efficiency than might be otherwise expected.

Magnetic seed

Simulation

Magnetic nanoparticle

Magnetic drug targeting

High gradient magnetic separation (HGMS)

Författare

Adil Mardinoglu

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Journal of Magnetism and Magnetic Materials

Vol. 320 3272-3275

Styrkeområden

Livsvetenskaper och teknik

Ämneskategorier

Bioinformatik och systembiologi

Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi