Current Status of COVID-19 Therapies and Drug Repositioning Applications
Review article, 2020
The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2.
Health Sciences
Medicine
Author
Ozlem Altay
Royal Institute of Technology (KTH)
Elyas Mohammadi
Ferdowsi University of Mashhad
Royal Institute of Technology (KTH)
Simon Lam
King's College London
Hasan Turkez
Atatürk University
Jan Borén
Wallenberg Lab.
Jens B Nielsen
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Mathias Uhlen
Royal Institute of Technology (KTH)
Adil Mardinoglu
King's College London
Royal Institute of Technology (KTH)
iScience
25890042 (eISSN)
Vol. 23 7 101303Subject Categories
Pharmaceutical Sciences
Pharmacology and Toxicology
Social and Clinical Pharmacy
DOI
10.1016/j.isci.2020.101303