Current Status of COVID-19 Therapies and Drug Repositioning Applications
Reviewartikel, 2020

The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2.

Health Sciences

Medicine

Författare

Ozlem Altay

Kungliga Tekniska Högskolan (KTH)

Elyas Mohammadi

Ferdowsi University of Mashhad

Kungliga Tekniska Högskolan (KTH)

Simon Lam

King's College London

Hasan Turkez

Atatürk Üniversitesi

Jan Borén

Wallenberg Lab.

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Mathias Uhlen

Kungliga Tekniska Högskolan (KTH)

Adil Mardinoglu

King's College London

Kungliga Tekniska Högskolan (KTH)

iScience

25890042 (eISSN)

Vol. 23 7 101303

Ämneskategorier

Farmaceutisk vetenskap

Farmakologi och toxikologi

Samhällsfarmaci och klinisk farmaci

DOI

10.1016/j.isci.2020.101303

Mer information

Senast uppdaterat

2020-08-19