Current Status of COVID-19 Therapies and Drug Repositioning Applications
Reviewartikel, 2020
The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2.
Health Sciences
Medicine
Författare
Ozlem Altay
Kungliga Tekniska Högskolan (KTH)
Elyas Mohammadi
Ferdowsi University of Mashhad
Kungliga Tekniska Högskolan (KTH)
Simon Lam
King's College London
Hasan Turkez
Atatürk Üniversitesi
Jan Borén
Wallenberg Lab.
Jens B Nielsen
Chalmers, Biologi och bioteknik, Systembiologi
Mathias Uhlen
Kungliga Tekniska Högskolan (KTH)
Adil Mardinoglu
King's College London
Kungliga Tekniska Högskolan (KTH)
iScience
25890042 (eISSN)
Vol. 23 7 101303Ämneskategorier
Farmaceutisk vetenskap
Farmakologi och toxikologi
Samhällsfarmaci och klinisk farmaci
DOI
10.1016/j.isci.2020.101303