Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia
Journal article, 2019

Aims: The microsomal triglyceride transport protein (MTTP) is critical for assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins and is most abundant in the liver and intestine. Surprisingly, MTTP is also expressed in the heart. Here we tested the functional relevance of cardiac MTTP expression. Materials and methods: We combined clinical studies, advanced expression analysis of human heart biopsies and analyses in genetically modified mice lacking cardiac expression of the MTTP-A isoform of MTTP. Results: Our results indicate that lower cardiac MTTP expression in humans is associated with structural and perfusion abnormalities in patients with ischemic heart disease. MTTP-A deficiency in mice heart does not affect total MTTP expression, activity or lipid concentration in the heart. Despite this, MTTP-A deficient mice displayed impaired cardiac function after a myocardial infarction. Expression analysis of MTTP indicates that MTTP expression is linked to cardiac function and responses in the heart. Conclusions: Our results indicate that MTTP may play an important role for the heart function in conjunction to ischemic events.

Heart

Expression

MTTP

Function

Polymorphism

Author

M. Klevstig

Wallenberg Lab.

Muhammad Arif

Royal Institute of Technology (KTH)

Maria Mannila

Karolinska University Hospital

Sara Svedlund

Sahlgrenska University Hospital

Ismena Mardani

Wallenberg Lab.

Marcus Ståhlman

Wallenberg Lab.

Linda Andersson

Wallenberg Lab.

Malin Lindbom

Wallenberg Lab.

Azra Miljanovic

Wallenberg Lab.

Anders Franco-Cereceda

Karolinska University Hospital

Per Eriksson

Karolinska University Hospital

Anders Jeppsson

Wallenberg Lab.

Li-Ming Gan

AstraZeneca AB

Wallenberg Lab.

Malin Levin

Wallenberg Lab.

Adil Mardinoglu

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Royal Institute of Technology (KTH)

Ewa Ehrenborg

Karolinska University Hospital

Jan Borén

Wallenberg Lab.

Journal of Molecular and Cellular Cardiology

0022-2828 (ISSN) 1095-8584 (eISSN)

Vol. 137 1-8

Subject Categories

Clinical Laboratory Medicine

Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

Cardiac and Cardiovascular Systems

DOI

10.1016/j.yjmcc.2019.09.003

PubMed

31533023

More information

Latest update

12/16/2019