Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia
Artikel i vetenskaplig tidskrift, 2019

Aims: The microsomal triglyceride transport protein (MTTP) is critical for assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins and is most abundant in the liver and intestine. Surprisingly, MTTP is also expressed in the heart. Here we tested the functional relevance of cardiac MTTP expression. Materials and methods: We combined clinical studies, advanced expression analysis of human heart biopsies and analyses in genetically modified mice lacking cardiac expression of the MTTP-A isoform of MTTP. Results: Our results indicate that lower cardiac MTTP expression in humans is associated with structural and perfusion abnormalities in patients with ischemic heart disease. MTTP-A deficiency in mice heart does not affect total MTTP expression, activity or lipid concentration in the heart. Despite this, MTTP-A deficient mice displayed impaired cardiac function after a myocardial infarction. Expression analysis of MTTP indicates that MTTP expression is linked to cardiac function and responses in the heart. Conclusions: Our results indicate that MTTP may play an important role for the heart function in conjunction to ischemic events.

Heart

Expression

MTTP

Function

Polymorphism

Författare

M. Klevstig

Wallenberg Lab.

Muhammad Arif

Kungliga Tekniska Högskolan (KTH)

Maria Mannila

Karolinska universitetssjukhuset

Sara Svedlund

Sahlgrenska universitetssjukhuset

Ismena Mardani

Wallenberg Lab.

Marcus Ståhlman

Wallenberg Lab.

Linda Andersson

Wallenberg Lab.

Malin Lindbom

Wallenberg Lab.

Azra Miljanovic

Wallenberg Lab.

Anders Franco-Cereceda

Karolinska universitetssjukhuset

Per Eriksson

Karolinska universitetssjukhuset

Anders Jeppsson

Wallenberg Lab.

Li-Ming Gan

AstraZeneca AB

Wallenberg Lab.

Malin Levin

Wallenberg Lab.

Adil Mardinoglu

Chalmers, Biologi och bioteknik, Systembiologi

Kungliga Tekniska Högskolan (KTH)

Ewa Ehrenborg

Karolinska universitetssjukhuset

Jan Borén

Wallenberg Lab.

Journal of Molecular and Cellular Cardiology

0022-2828 (ISSN) 1095-8584 (eISSN)

Vol. 137 1-8

Ämneskategorier

Klinisk laboratoriemedicin

Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

Kardiologi

DOI

10.1016/j.yjmcc.2019.09.003

PubMed

31533023

Mer information

Senast uppdaterat

2019-12-16