Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia
Artikel i vetenskaplig tidskrift, 2019
Aims: The microsomal triglyceride transport protein (MTTP) is critical for assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins and is most abundant in the liver and intestine. Surprisingly, MTTP is also expressed in the heart. Here we tested the functional relevance of cardiac MTTP expression. Materials and methods: We combined clinical studies, advanced expression analysis of human heart biopsies and analyses in genetically modified mice lacking cardiac expression of the MTTP-A isoform of MTTP. Results: Our results indicate that lower cardiac MTTP expression in humans is associated with structural and perfusion abnormalities in patients with ischemic heart disease. MTTP-A deficiency in mice heart does not affect total MTTP expression, activity or lipid concentration in the heart. Despite this, MTTP-A deficient mice displayed impaired cardiac function after a myocardial infarction. Expression analysis of MTTP indicates that MTTP expression is linked to cardiac function and responses in the heart. Conclusions: Our results indicate that MTTP may play an important role for the heart function in conjunction to ischemic events.
Heart
Polymorphism
Function
Expression
MTTP
Författare
M. Klevstig
Wallenberg Lab.
Muhammad Arif
Kungliga Tekniska Högskolan (KTH)
Maria Mannila
Karolinska universitetssjukhuset
Sara Svedlund
Sahlgrenska universitetssjukhuset
Ismena Mardani
Wallenberg Lab.
Marcus Ståhlman
Wallenberg Lab.
Linda Andersson
Wallenberg Lab.
Malin Lindbom
Wallenberg Lab.
Azra Miljanovic
Wallenberg Lab.
Anders Franco-Cereceda
Karolinska universitetssjukhuset
Per Eriksson
Karolinska universitetssjukhuset
Anders Jeppsson
Wallenberg Lab.
Li-Ming Gan
Wallenberg Lab.
AstraZeneca AB
Malin Levin
Wallenberg Lab.
Adil Mardinoglu
Kungliga Tekniska Högskolan (KTH)
Chalmers, Biologi och bioteknik, Systembiologi
Ewa Ehrenborg
Karolinska universitetssjukhuset
Jan Borén
Wallenberg Lab.
Journal of Molecular and Cellular Cardiology
0022-2828 (ISSN) 1095-8584 (eISSN)
Vol. 137 1-8Ämneskategorier
Klinisk laboratoriemedicin
Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)
Kardiologi
DOI
10.1016/j.yjmcc.2019.09.003
PubMed
31533023