Genome-scale metabolic models of Saccharomyces cerevisiae
Book chapter, 2011

Systematic analysis of Saccharomyces cerevisiae metabolic functions and pathways has been the subject of extensive studies and established in many aspects. With the reconstruction of the yeast genome-scale metabolic (GSM) network and in silico simulation of the GSM model, the nature of the underlying cellular processes can be tested and validated with the increasing metabolic knowledge. GSM models are also being exploited in fundamental research studies and industrial applications. In this chapter, the principle concepts for construction, simulation and validation of GSM models, progressive applications of the yeast GSM models, and future perspectives are described. This will support and encourage researchers who are interested in systemic analysis of yeast metabolism and systems biology.

genome-scale metabolic model (GSM)

yeast

metabolism

Saccharomyces cerevisia

metabolic network reconstruction

systems biology

Author

Intawat Nookaew

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Roberto Olivares Hernandez

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

S. Bhumiratana

Thailand National Science and Technology Development Agency

Jens B Nielsen

Chalmers, Chemical and Biological Engineering, Life Sciences, System Biology

Methods in Molecular Biology

10643745 (ISSN)

445-463

Subject Categories

Biochemistry and Molecular Biology

Areas of Advance

Life Science Engineering (2010-2018)

DOI

10.1007/978-1-61779-173-4_25

ISBN

978-161779172-7

More information

Created

10/7/2017